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Multiplex detection of mutations in clinical isolates of rifampin-resistant Mycobacterium tuberculosis by short oligonucleotide Ligation assay on DNA chips
Jiao-Yu Deng; Xian-En Zhang; Hong-Bing Lu; Qiang Liu; Zhi-Ping Zhang; Ya-Feng Zhou; Wei-Hong Xie and Zhi-Jun Fu; Zhang, XE, Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China
2004
Source PublicationJOURNAL OF CLINICAL MICROBIOLOGY
Volume42Issue:10Pages:4850-4852
AbstractA new approach, short-oligonucleotide-ligation assay on DNA chip (SOLAC), is developed to detect mutations in rifampin-resistant Mycobacterium tuberculosis. The method needs only four common probes to detect 15 mutational variants of the rpoB gene within 12 h. Fifty-five rifampin-resistant M. tuberculosis isolates were analyzed, resulting in 87.3% accuracy and 83.6% concordance relative to DNA sequencing.
KeywordPolymerase-chain-reaction Line Probe Assay Rapid Detection Drug-resistance Rpob Mutations Gene Strains
DepartmentChinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China; Chinese Acad Sci, Wuhan Inst Hydrobiol, Wuhan 430071, Peoples R China; Wuhan TB Prevent & Cure Inst, Wuhan, Peoples R China
Subject AreaMicrobiology
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9400
Collection期刊论文
Corresponding AuthorZhang, XE, Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China
Recommended Citation
GB/T 7714
Jiao-Yu Deng,Xian-En Zhang,Hong-Bing Lu,et al. Multiplex detection of mutations in clinical isolates of rifampin-resistant Mycobacterium tuberculosis by short oligonucleotide Ligation assay on DNA chips[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2004,42(10):4850-4852.
APA Jiao-Yu Deng.,Xian-En Zhang.,Hong-Bing Lu.,Qiang Liu.,Zhi-Ping Zhang.,...&Zhang, XE, Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China.(2004).Multiplex detection of mutations in clinical isolates of rifampin-resistant Mycobacterium tuberculosis by short oligonucleotide Ligation assay on DNA chips.JOURNAL OF CLINICAL MICROBIOLOGY,42(10),4850-4852.
MLA Jiao-Yu Deng,et al."Multiplex detection of mutations in clinical isolates of rifampin-resistant Mycobacterium tuberculosis by short oligonucleotide Ligation assay on DNA chips".JOURNAL OF CLINICAL MICROBIOLOGY 42.10(2004):4850-4852.
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