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Growth and antioxidant system of the cyanobacterium Synechococcus elongatus in response to microcystin-RR
Hu, ZQ; Liu, YD; Li, DH; Dauta, A; Liu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2005-02-01
Source PublicationHYDROBIOLOGIA
ISSN0018-8158
Volume534Issue:1-3Pages:23-29
AbstractMicrocystins, one type of the cyanobacterial toxins, show a broad range of hazardous effects on other organisms. Most of the researches on the toxic effects of microcystins have involved in animals and higher plants. Little work, however, has been done on evaluating the mechanisms of microcystin toxicity on algae. In this study, the toxicological effects of microcystin-RR (MC-RR) on the cyanobacterium Synechococcus elongatus were investigated. For this purpose, six physio-biochemical parameters (cell optical density, reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST)) were tested in algal cells when exposed to 100 mug(-1) microcystin-RR. The results showed that the growth of Synechococcus elongatus ( expressed as optical density) was significantly inhibited compared with the control. At the same time, the treated algae exhibited a pronounced increase in production of ROS and MDA after 6 days exposure to microcystin-RR. Signi. cant changes in GSH levels and GSH-Px, GSH activities were also detected in algal cells, with higher values being observed in the toxin treated algae after 6 days exposure. GST activities in the treated algae exhibited a decline after exposure and rapid augmentation on day 3, thereafter, they kept at a high level when compared to the control group. GSH contents and GSH-Px activities were also significantly raised in the toxin-treated algae cells from day 3, but they showed a sharp decrease on day 4, which was the onward of cell proliferation. These results suggested that oxidative stress manifested by elevated ROS levels and MDA contents might be responsible for the toxicity of microcystin to Synechococcus elongatus and the algal cells could improve their antioxidant ability through the enhancement of enzymatic and non-enzymatic preventive substances.; Microcystins, one type of the cyanobacterial toxins, show a broad range of hazardous effects on other organisms. Most of the researches on the toxic effects of microcystins have involved in animals and higher plants. Little work, however, has been done on evaluating the mechanisms of microcystin toxicity on algae. In this study, the toxicological effects of microcystin-RR (MC-RR) on the cyanobacterium Synechococcus elongatus were investigated. For this purpose, six physio-biochemical parameters (cell optical density, reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST)) were tested in algal cells when exposed to 100 mug(-1) microcystin-RR. The results showed that the growth of Synechococcus elongatus ( expressed as optical density) was significantly inhibited compared with the control. At the same time, the treated algae exhibited a pronounced increase in production of ROS and MDA after 6 days exposure to microcystin-RR. Signi. cant changes in GSH levels and GSH-Px, GSH activities were also detected in algal cells, with higher values being observed in the toxin treated algae after 6 days exposure. GST activities in the treated algae exhibited a decline after exposure and rapid augmentation on day 3, thereafter, they kept at a high level when compared to the control group. GSH contents and GSH-Px activities were also significantly raised in the toxin-treated algae cells from day 3, but they showed a sharp decrease on day 4, which was the onward of cell proliferation. These results suggested that oxidative stress manifested by elevated ROS levels and MDA contents might be responsible for the toxicity of microcystin to Synechococcus elongatus and the algal cells could improve their antioxidant ability through the enhancement of enzymatic and non-enzymatic preventive substances.
SubtypeArticle
KeywordMicrocystin-rr Growth Antioxidant System Synechococcus Elongatus Toxicity
DepartmentChinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; Lab Ecol Hydrosyst, F-31062 Toulouse 04, France
Subject AreaMarine & Freshwater Biology
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaMarine & Freshwater Biology
WOS SubjectMarine & Freshwater Biology
WOS IDWOS:000227070700003
WOS KeywordOXIDATIVE STRESS ; GLUTATHIONE ; TOXINS ; PLANTS ; LR ; PHOSPHORYLATION ; PHOSPHATASES ; EXPOSURE ; QUALITY
Citation statistics
Cited Times:48[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9322
Collection期刊论文
Corresponding AuthorLiu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Lab Ecol Hydrosyst, F-31062 Toulouse 04, France
Recommended Citation
GB/T 7714
Hu, ZQ,Liu, YD,Li, DH,et al. Growth and antioxidant system of the cyanobacterium Synechococcus elongatus in response to microcystin-RR[J]. HYDROBIOLOGIA,2005,534(1-3):23-29.
APA Hu, ZQ,Liu, YD,Li, DH,Dauta, A,&Liu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.(2005).Growth and antioxidant system of the cyanobacterium Synechococcus elongatus in response to microcystin-RR.HYDROBIOLOGIA,534(1-3),23-29.
MLA Hu, ZQ,et al."Growth and antioxidant system of the cyanobacterium Synechococcus elongatus in response to microcystin-RR".HYDROBIOLOGIA 534.1-3(2005):23-29.
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