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学科主题: Biochemical Research Methods; Chemistry, Analytical
题名: Evaluation of soot particles of biomass fuels with endocrine-modulating activity in yeast-based bioassay
作者: Wang, JX; Xie, P; Kettrup, A; Schramm, KW
通讯作者: Schramm, KW, GSF NAtl Res Ctr Environm & Hlth, Inst Ecol Chem, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany
关键词: biomass fuel ; soot ; endocrine modulating disrupter ; yeast bioassay ; Reproductive health
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2005-04-01
DOI: 10.1007/s00216-005-3096-5
卷: 381, 期:8, 页:1609-1618
收录类别: SCI
文章类型: Article
部门归属: GSF NAtl Res Ctr Environm & Hlth, Inst Ecol Chem, D-85764 Neuherberg, Germany; Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; Tech Univ Munich, Lehrstuhl Okol Chem & Umweltanalyt, D-85350 Freising Weihenstephan, Weihenstephan, Germany
WOS标题词: Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
摘要: Exposure to indoor air pollution (IAP) from the combustion of biomass fuels is an important cause of morbidity and mortality in developing countries. In the work discussed in this paper we evaluated the endocrine activity of soot particles from biomass fuels by using yeast bioassay. These pollutants could have beta-galactosidase activity with a relative potency (RP) about 10(-7)-10(-9) that of estradiol. Soot particles from wood and straw combustion only partially induced beta-galactosidase activity whereas others produced fully inductive activity in the yeast assay system. These pollutants did not have estrogen antagonist and progesterone agonist activity within the defined concentration range. However, these pollutants require 2-4 orders of magnitude higher IC50 to inhibit the activity of progesterone in a similar dose-response manner to mifepristone. We therefore propose that the endocrine activity of some environmental pollutants may be because of inhibition of the progesterone receptor (hPR). GC-MS results showed that substituted polycyclic aromatic hydrocarbon (PAH) compounds, substituted phenolic compounds and derivatives, aromatic carbonyl compounds, and phytosteroids in these soot particles may be mimicking endogenous hormones.
英文摘要: Exposure to indoor air pollution (IAP) from the combustion of biomass fuels is an important cause of morbidity and mortality in developing countries. In the work discussed in this paper we evaluated the endocrine activity of soot particles from biomass fuels by using yeast bioassay. These pollutants could have beta-galactosidase activity with a relative potency (RP) about 10(-7)-10(-9) that of estradiol. Soot particles from wood and straw combustion only partially induced beta-galactosidase activity whereas others produced fully inductive activity in the yeast assay system. These pollutants did not have estrogen antagonist and progesterone agonist activity within the defined concentration range. However, these pollutants require 2-4 orders of magnitude higher IC50 to inhibit the activity of progesterone in a similar dose-response manner to mifepristone. We therefore propose that the endocrine activity of some environmental pollutants may be because of inhibition of the progesterone receptor (hPR). GC-MS results showed that substituted polycyclic aromatic hydrocarbon (PAH) compounds, substituted phenolic compounds and derivatives, aromatic carbonyl compounds, and phytosteroids in these soot particles may be mimicking endogenous hormones.
关键词[WOS]: PARTICULATE AIR-POLLUTION ; FINE ORGANIC AEROSOL ; ESTROGEN-RECEPTOR ; ENVIRONMENTAL ESTROGENS ; BREAST-CANCER ; WOOD SMOKE ; COMBUSTION ; CHEMICALS ; ASSAY ; PROGESTERONE
语种: 英语
WOS记录号: WOS:000228728200019
ISSN号: 1618-2642
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/9280
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.GSF NAtl Res Ctr Environm & Hlth, Inst Ecol Chem, D-85764 Neuherberg, Germany
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
3.Tech Univ Munich, Lehrstuhl Okol Chem & Umweltanalyt, D-85350 Freising Weihenstephan, Weihenstephan, Germany

Recommended Citation:
Wang, JX; Xie, P; Kettrup, A; Schramm, KW.Evaluation of soot particles of biomass fuels with endocrine-modulating activity in yeast-based bioassay,ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2005,381(8):1609-1618
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