| Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism | |
| Yang, FX; Xu, Y; Yang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China | |
| 2005-07-01 | |
| Source Publication | PROGRESS IN CHEMISTRY
 |
| ISSN | 1005-281X |
| Volume | 17Issue:4Pages:740-748 |
| Abstract | Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China.; Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China. |
| Subtype | Article |
| Keyword | Polychlorinated Biphenyls Hydroxylated Polychlorinated Biphenyls Oh-pcbs Endocrine Disruption |
| Department | Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| Subject Area | Chemistry ; Multidisciplinary |
| WOS Headings | Science & Technology ; Physical Sciences |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000230693700022 |
| WOS Keyword | CEREBELLAR GRANULE CELLS ; ESTROGEN-RECEPTOR ; PCB METABOLITES ; METHYL SULFONE ; BINDING ; CONGENERS ; TRANSTHYRETIN ; PLASMA ; 3,4,3',4'-TETRACHLOROBIPHENYL ; IDENTIFICATION |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/152342/9204 |
| Collection | 期刊论文 |
| Corresponding Author | Yang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, FX,Xu, Y,Yang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China. Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism[J]. PROGRESS IN CHEMISTRY,2005,17(4):740-748. |
| APA | Yang, FX,Xu, Y,&Yang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2005).Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism.PROGRESS IN CHEMISTRY,17(4),740-748. |
| MLA | Yang, FX,et al."Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism".PROGRESS IN CHEMISTRY 17.4(2005):740-748. |
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