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Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism
Yang, FX; Xu, Y; Yang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2005-07-01
Source PublicationPROGRESS IN CHEMISTRY
ISSN1005-281X
Volume17Issue:4Pages:740-748
AbstractHydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China.; Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China.
SubtypeArticle
KeywordPolychlorinated Biphenyls Hydroxylated Polychlorinated Biphenyls Oh-pcbs Endocrine Disruption
DepartmentChinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Subject AreaChemistry ; Multidisciplinary
WOS HeadingsScience & Technology ; Physical Sciences
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000230693700022
WOS KeywordCEREBELLAR GRANULE CELLS ; ESTROGEN-RECEPTOR ; PCB METABOLITES ; METHYL SULFONE ; BINDING ; CONGENERS ; TRANSTHYRETIN ; PLASMA ; 3,4,3',4'-TETRACHLOROBIPHENYL ; IDENTIFICATION
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9204
Collection期刊论文
Corresponding AuthorYang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Yang, FX,Xu, Y,Yang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China. Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism[J]. PROGRESS IN CHEMISTRY,2005,17(4):740-748.
APA Yang, FX,Xu, Y,&Yang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2005).Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism.PROGRESS IN CHEMISTRY,17(4),740-748.
MLA Yang, FX,et al."Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism".PROGRESS IN CHEMISTRY 17.4(2005):740-748.
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