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学科主题: Chemistry ; Multidisciplinary
题名: Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism
作者: Yang, FX; Xu, Y
通讯作者: Yang, FX, Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
关键词: polychlorinated biphenyls ; hydroxylated polychlorinated biphenyls ; OH-PCBs ; endocrine disruption
刊名: PROGRESS IN CHEMISTRY
发表日期: 2005-07-01
卷: 17, 期:4, 页:740-748
收录类别: SCI
文章类型: Article
部门归属: Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
WOS标题词: Science & Technology ; Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
摘要: Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China.
英文摘要: Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China.
关键词[WOS]: CEREBELLAR GRANULE CELLS ; ESTROGEN-RECEPTOR ; PCB METABOLITES ; METHYL SULFONE ; BINDING ; CONGENERS ; TRANSTHYRETIN ; PLASMA ; 3,4,3',4'-TETRACHLOROBIPHENYL ; IDENTIFICATION
语种: 英语
WOS记录号: WOS:000230693700022
ISSN号: 1005-281X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/9204
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Yang, FX; Xu, Y.Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism,PROGRESS IN CHEMISTRY,2005,17(4):740-748
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