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学科主题: Environmental Sciences
题名: Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis
作者: Lutz, I; Jie, Z; Opitz, R; Kloas, W; Ying, X; Menzel, R; Steinberg, CEW
通讯作者: Steinberg, CEW, Leibniz Inst Freshwater Ecol & Inland Fisheries, Muggelseedamm 310, D-12587 Berlin, Germany
关键词: estrogenic effect ; ER-mRNA ; TSH beta-mRNA ; clawed frog ; molecular biomarkers
刊名: CHEMOSPHERE
发表日期: 2005-12-01
DOI: 10.1016/j.chemosphere.2005.02.073
卷: 61, 期:8, 页:1183-1188
收录类别: SCI
文章类型: Article
部门归属: Leibniz Inst Freshwater Ecol & Inland Fisheries, D-12587 Berlin, Germany; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; Humboldt Univ, Inst Biol, D-10099 Berlin, Germany
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
摘要: According to outdated paradigms humic substances (HS) are considered to be refractory or inert that do not directly interact with aquatic organisms. However, they are taken up and induce biotransformation activities and may act as hormone-like substances. In the present study, we tested whether HS can interfere with endocrine regulation in the amphibian Xenopus laevis. In order to exclude contamination with phyto-hormones, which may occur in environmental isolates, the artificial HS 1500 was applied. The in vivo results showed that HS 1500 causes significant estrogenic effects on X. laevis during its larval development and results of semi-quantitative RT-PCR revealed a marked increase of the estrogenic biomarker estrogen receptor mRNA (ER-mRNA). Furthermore, preliminary RT-PCR results showed that the thyroid-stimulating hormone (TSH beta-mRNA) is enhanced after exposure to HS1500, indicating a weak adverse effect on T3/T4 availability. Hence, HS may have estrogenic and anti-thyroidal effects on aquatic animals, and therefore may influence the structure of aquatic communities and they may be considered environmental signaling chemicals. (c) 2005 Elsevier Ltd. All rights reserved.
英文摘要: According to outdated paradigms humic substances (HS) are considered to be refractory or inert that do not directly interact with aquatic organisms. However, they are taken up and induce biotransformation activities and may act as hormone-like substances. In the present study, we tested whether HS can interfere with endocrine regulation in the amphibian Xenopus laevis. In order to exclude contamination with phyto-hormones, which may occur in environmental isolates, the artificial HS 1500 was applied. The in vivo results showed that HS 1500 causes significant estrogenic effects on X. laevis during its larval development and results of semi-quantitative RT-PCR revealed a marked increase of the estrogenic biomarker estrogen receptor mRNA (ER-mRNA). Furthermore, preliminary RT-PCR results showed that the thyroid-stimulating hormone (TSH beta-mRNA) is enhanced after exposure to HS1500, indicating a weak adverse effect on T3/T4 availability. Hence, HS may have estrogenic and anti-thyroidal effects on aquatic animals, and therefore may influence the structure of aquatic communities and they may be considered environmental signaling chemicals. (c) 2005 Elsevier Ltd. All rights reserved.
关键词[WOS]: SIZE-EXCLUSION CHROMATOGRAPHY ; DISSOLVED ORGANIC-MATTER ; ENDOCRINE DISRUPTORS ; CAENORHABDITIS-ELEGANS ; MASS-SPECTROMETRY ; AMPHIBIANS ; CHEMICALS ; MODEL ; REPRODUCTION ; ACIDS
语种: 英语
WOS记录号: WOS:000233381100014
ISSN号: 0045-6535
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/9100
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Leibniz Inst Freshwater Ecol & Inland Fisheries, D-12587 Berlin, Germany
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
3.Humboldt Univ, Inst Biol, D-10099 Berlin, Germany

Recommended Citation:
Lutz, I; Jie, Z; Opitz, R; Kloas, W; Ying, X; Menzel, R; Steinberg, CEW.Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis,CHEMOSPHERE,2005,61(8):1183-1188
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