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Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis
Lutz, I; Jie, Z; Opitz, R; Kloas, W; Ying, X; Menzel, R; Steinberg, CEW; Steinberg, CEW, Leibniz Inst Freshwater Ecol & Inland Fisheries, Muggelseedamm 310, D-12587 Berlin, Germany
2005-12-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume61Issue:8Pages:1183-1188
AbstractAccording to outdated paradigms humic substances (HS) are considered to be refractory or inert that do not directly interact with aquatic organisms. However, they are taken up and induce biotransformation activities and may act as hormone-like substances. In the present study, we tested whether HS can interfere with endocrine regulation in the amphibian Xenopus laevis. In order to exclude contamination with phyto-hormones, which may occur in environmental isolates, the artificial HS 1500 was applied. The in vivo results showed that HS 1500 causes significant estrogenic effects on X. laevis during its larval development and results of semi-quantitative RT-PCR revealed a marked increase of the estrogenic biomarker estrogen receptor mRNA (ER-mRNA). Furthermore, preliminary RT-PCR results showed that the thyroid-stimulating hormone (TSH beta-mRNA) is enhanced after exposure to HS1500, indicating a weak adverse effect on T3/T4 availability. Hence, HS may have estrogenic and anti-thyroidal effects on aquatic animals, and therefore may influence the structure of aquatic communities and they may be considered environmental signaling chemicals. (c) 2005 Elsevier Ltd. All rights reserved.; According to outdated paradigms humic substances (HS) are considered to be refractory or inert that do not directly interact with aquatic organisms. However, they are taken up and induce biotransformation activities and may act as hormone-like substances. In the present study, we tested whether HS can interfere with endocrine regulation in the amphibian Xenopus laevis. In order to exclude contamination with phyto-hormones, which may occur in environmental isolates, the artificial HS 1500 was applied. The in vivo results showed that HS 1500 causes significant estrogenic effects on X. laevis during its larval development and results of semi-quantitative RT-PCR revealed a marked increase of the estrogenic biomarker estrogen receptor mRNA (ER-mRNA). Furthermore, preliminary RT-PCR results showed that the thyroid-stimulating hormone (TSH beta-mRNA) is enhanced after exposure to HS1500, indicating a weak adverse effect on T3/T4 availability. Hence, HS may have estrogenic and anti-thyroidal effects on aquatic animals, and therefore may influence the structure of aquatic communities and they may be considered environmental signaling chemicals. (c) 2005 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordEstrogenic Effect Er-mrna Tsh Beta-mrna Clawed Frog Molecular Biomarkers
DepartmentLeibniz Inst Freshwater Ecol & Inland Fisheries, D-12587 Berlin, Germany; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; Humboldt Univ, Inst Biol, D-10099 Berlin, Germany
Subject AreaEnvironmental Sciences
DOI10.1016/j.chemosphere.2005.02.073
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000233381100014
WOS KeywordSIZE-EXCLUSION CHROMATOGRAPHY ; DISSOLVED ORGANIC-MATTER ; ENDOCRINE DISRUPTORS ; CAENORHABDITIS-ELEGANS ; MASS-SPECTROMETRY ; AMPHIBIANS ; CHEMICALS ; MODEL ; REPRODUCTION ; ACIDS
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9100
Collection期刊论文
Corresponding AuthorSteinberg, CEW, Leibniz Inst Freshwater Ecol & Inland Fisheries, Muggelseedamm 310, D-12587 Berlin, Germany
Affiliation1.Leibniz Inst Freshwater Ecol & Inland Fisheries, D-12587 Berlin, Germany
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
3.Humboldt Univ, Inst Biol, D-10099 Berlin, Germany
Recommended Citation
GB/T 7714
Lutz, I,Jie, Z,Opitz, R,et al. Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis[J]. CHEMOSPHERE,2005,61(8):1183-1188.
APA Lutz, I.,Jie, Z.,Opitz, R.,Kloas, W.,Ying, X.,...&Steinberg, CEW, Leibniz Inst Freshwater Ecol & Inland Fisheries, Muggelseedamm 310, D-12587 Berlin, Germany.(2005).Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis.CHEMOSPHERE,61(8),1183-1188.
MLA Lutz, I,et al."Environmental signals: Synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis".CHEMOSPHERE 61.8(2005):1183-1188.
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