| Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck) | |
| Guo, S; Chen, NH; Guan, R; Feng, J; Huang, W; Guo, S, Coll JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China | |
| 2006-02-01 | |
| Source Publication | POULTRY SCIENCE
 |
| ISSN | 0032-5791 |
| Volume | 85Issue:2Pages:258-265 |
| Abstract | To study the immunologic function of bursin, we analyzed the effects of anti-bursin monoclonal antibody (mAb) on the immunosuppression in ducks (Cherry Valley duck) by injecting various doses of the anti-bursin mAb into 13-d duck embryos. After hatch, cell-mediated immune activity and humoral responses were studied using lymphocyte proliferation test, tube agglutination test, and indirect enzyme-linked immuno-sorbent assay to detect anti-Escherichia coli antibodies and antibodies to Riemerella anatipester, respectively. Simultaneously, relative weights (BW-adjusted) of bursa of Fabricius (BF), spleen, and thymus were determined. Additionally, the morphology of BF, spleen, and thymus was examined at various ages using conventional histology. Follicle morphology of BF was analyzed by image analysis. The results indicated that anti-bursin mAb markedly decreased duck lymphocyte proliferation, the antibody-producing ability to bacteria, as well as the relative BF weight. Moreover, the anti-bursin mAb hindered the development of BF follicles.; To study the immunologic function of bursin, we analyzed the effects of anti-bursin monoclonal antibody (mAb) on the immunosuppression in ducks (Cherry Valley duck) by injecting various doses of the anti-bursin mAb into 13-d duck embryos. After hatch, cell-mediated immune activity and humoral responses were studied using lymphocyte proliferation test, tube agglutination test, and indirect enzyme-linked immuno-sorbent assay to detect anti-Escherichia coli antibodies and antibodies to Riemerella anatipester, respectively. Simultaneously, relative weights (BW-adjusted) of bursa of Fabricius (BF), spleen, and thymus were determined. Additionally, the morphology of BF, spleen, and thymus was examined at various ages using conventional histology. Follicle morphology of BF was analyzed by image analysis. The results indicated that anti-bursin mAb markedly decreased duck lymphocyte proliferation, the antibody-producing ability to bacteria, as well as the relative BF weight. Moreover, the anti-bursin mAb hindered the development of BF follicles. |
| Subtype | Article |
| Keyword | Cherry Valley Duck Bursin Anti-bursin Monoclonal Antibody Immunosuppression Immune Function |
| Department | Coll JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; JiangXi Agr Univ, Dept Anim Sci, Nanchang 330045, Peoples R China |
| Subject Area | Agriculture, Dairy & Animal Science |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Agriculture |
| WOS Subject | Agriculture, Dairy & Animal Science |
| WOS ID | WOS:000235042800018 |
| WOS Keyword | DIFFERENTIATING HORMONE ; EMBRYONIC BURSECTOMY ; FABRICIUS ; CHICKENS ; RESPONSES |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/152342/9038 |
| Collection | 期刊论文 |
| Corresponding Author | Guo, S, Coll JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China |
| Affiliation | 1.Coll JiMei Univ, Anim Sci Dept Aquaculture, XiaMen 361021, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.JiangXi Agr Univ, Dept Anim Sci, Nanchang 330045, Peoples R China |
| Recommended Citation GB/T 7714 | Guo, S,Chen, NH,Guan, R,et al. Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck)[J]. POULTRY SCIENCE,2006,85(2):258-265. |
| APA | Guo, S,Chen, NH,Guan, R,Feng, J,Huang, W,&Guo, S, Coll JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China.(2006).Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck).POULTRY SCIENCE,85(2),258-265. |
| MLA | Guo, S,et al."Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck)".POULTRY SCIENCE 85.2(2006):258-265. |
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