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Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck)
Guo, S; Chen, NH; Guan, R; Feng, J; Huang, W; Guo, S, Coll JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China
2006-02-01
Source PublicationPOULTRY SCIENCE
ISSN0032-5791
Volume85Issue:2Pages:258-265
AbstractTo study the immunologic function of bursin, we analyzed the effects of anti-bursin monoclonal antibody (mAb) on the immunosuppression in ducks (Cherry Valley duck) by injecting various doses of the anti-bursin mAb into 13-d duck embryos. After hatch, cell-mediated immune activity and humoral responses were studied using lymphocyte proliferation test, tube agglutination test, and indirect enzyme-linked immuno-sorbent assay to detect anti-Escherichia coli antibodies and antibodies to Riemerella anatipester, respectively. Simultaneously, relative weights (BW-adjusted) of bursa of Fabricius (BF), spleen, and thymus were determined. Additionally, the morphology of BF, spleen, and thymus was examined at various ages using conventional histology. Follicle morphology of BF was analyzed by image analysis. The results indicated that anti-bursin mAb markedly decreased duck lymphocyte proliferation, the antibody-producing ability to bacteria, as well as the relative BF weight. Moreover, the anti-bursin mAb hindered the development of BF follicles.; To study the immunologic function of bursin, we analyzed the effects of anti-bursin monoclonal antibody (mAb) on the immunosuppression in ducks (Cherry Valley duck) by injecting various doses of the anti-bursin mAb into 13-d duck embryos. After hatch, cell-mediated immune activity and humoral responses were studied using lymphocyte proliferation test, tube agglutination test, and indirect enzyme-linked immuno-sorbent assay to detect anti-Escherichia coli antibodies and antibodies to Riemerella anatipester, respectively. Simultaneously, relative weights (BW-adjusted) of bursa of Fabricius (BF), spleen, and thymus were determined. Additionally, the morphology of BF, spleen, and thymus was examined at various ages using conventional histology. Follicle morphology of BF was analyzed by image analysis. The results indicated that anti-bursin mAb markedly decreased duck lymphocyte proliferation, the antibody-producing ability to bacteria, as well as the relative BF weight. Moreover, the anti-bursin mAb hindered the development of BF follicles.
SubtypeArticle
KeywordCherry Valley Duck Bursin Anti-bursin Monoclonal Antibody Immunosuppression Immune Function
DepartmentColl JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; JiangXi Agr Univ, Dept Anim Sci, Nanchang 330045, Peoples R China
Subject AreaAgriculture, Dairy & Animal Science
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaAgriculture
WOS SubjectAgriculture, Dairy & Animal Science
WOS IDWOS:000235042800018
WOS KeywordDIFFERENTIATING HORMONE ; EMBRYONIC BURSECTOMY ; FABRICIUS ; CHICKENS ; RESPONSES
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9038
Collection期刊论文
Corresponding AuthorGuo, S, Coll JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China
Affiliation1.Coll JiMei Univ, Anim Sci Dept Aquaculture, XiaMen 361021, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.JiangXi Agr Univ, Dept Anim Sci, Nanchang 330045, Peoples R China
Recommended Citation
GB/T 7714
Guo, S,Chen, NH,Guan, R,et al. Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck)[J]. POULTRY SCIENCE,2006,85(2):258-265.
APA Guo, S,Chen, NH,Guan, R,Feng, J,Huang, W,&Guo, S, Coll JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China.(2006).Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck).POULTRY SCIENCE,85(2),258-265.
MLA Guo, S,et al."Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck)".POULTRY SCIENCE 85.2(2006):258-265.
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