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学科主题: Agriculture, Dairy & Animal Science
题名: Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck)
作者: Guo, S; Chen, NH; Guan, R; Feng, J; Huang, W
通讯作者: Guo, S, Coll JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China
关键词: Cherry Valley duck ; bursin ; anti-bursin monoclonal antibody ; immunosuppression ; immune function
刊名: POULTRY SCIENCE
发表日期: 2006-02-01
卷: 85, 期:2, 页:258-265
收录类别: SCI
文章类型: Article
部门归属: Coll JiMei Univ, Anim Sci Dpet Aquaculture, XiaMen 361021, Peoples R China; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; JiangXi Agr Univ, Dept Anim Sci, Nanchang 330045, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Agriculture, Dairy & Animal Science
研究领域[WOS]: Agriculture
摘要: To study the immunologic function of bursin, we analyzed the effects of anti-bursin monoclonal antibody (mAb) on the immunosuppression in ducks (Cherry Valley duck) by injecting various doses of the anti-bursin mAb into 13-d duck embryos. After hatch, cell-mediated immune activity and humoral responses were studied using lymphocyte proliferation test, tube agglutination test, and indirect enzyme-linked immuno-sorbent assay to detect anti-Escherichia coli antibodies and antibodies to Riemerella anatipester, respectively. Simultaneously, relative weights (BW-adjusted) of bursa of Fabricius (BF), spleen, and thymus were determined. Additionally, the morphology of BF, spleen, and thymus was examined at various ages using conventional histology. Follicle morphology of BF was analyzed by image analysis. The results indicated that anti-bursin mAb markedly decreased duck lymphocyte proliferation, the antibody-producing ability to bacteria, as well as the relative BF weight. Moreover, the anti-bursin mAb hindered the development of BF follicles.
英文摘要: To study the immunologic function of bursin, we analyzed the effects of anti-bursin monoclonal antibody (mAb) on the immunosuppression in ducks (Cherry Valley duck) by injecting various doses of the anti-bursin mAb into 13-d duck embryos. After hatch, cell-mediated immune activity and humoral responses were studied using lymphocyte proliferation test, tube agglutination test, and indirect enzyme-linked immuno-sorbent assay to detect anti-Escherichia coli antibodies and antibodies to Riemerella anatipester, respectively. Simultaneously, relative weights (BW-adjusted) of bursa of Fabricius (BF), spleen, and thymus were determined. Additionally, the morphology of BF, spleen, and thymus was examined at various ages using conventional histology. Follicle morphology of BF was analyzed by image analysis. The results indicated that anti-bursin mAb markedly decreased duck lymphocyte proliferation, the antibody-producing ability to bacteria, as well as the relative BF weight. Moreover, the anti-bursin mAb hindered the development of BF follicles.
关键词[WOS]: DIFFERENTIATING HORMONE ; EMBRYONIC BURSECTOMY ; FABRICIUS ; CHICKENS ; RESPONSES
语种: 英语
WOS记录号: WOS:000235042800018
ISSN号: 0032-5791
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/9038
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Coll JiMei Univ, Anim Sci Dept Aquaculture, XiaMen 361021, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.JiangXi Agr Univ, Dept Anim Sci, Nanchang 330045, Peoples R China

Recommended Citation:
Guo, S; Chen, NH; Guan, R; Feng, J; Huang, W.Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck),POULTRY SCIENCE,2006,85(2):258-265
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