IHB OpenIR  > 期刊论文
Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth
Zheng, Dan; Liu, Yi; Zhang, Yue; Chen, Xiao-Juan; Shen, Yun-Fen; Liu, Y, Wuhan Univ, Coll Chem & Mol Sci, Dept Biol Chem, Wuhan 430072, Peoples R China
2006-09-01
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
Volume22Issue:2Pages:121-127
AbstractTetrahymena thermophila BF5 produce heat by metabolism and movement. Using a TAM air isothermal microcalorimeter, the power-time curves of the metabolism of T thermophila BF5 during growth were obtained and the action on them by the addition of Cr(VI) were studied. The morphological change with Cr(VI) coexisted and biomass change during the process of T thermophila BF5 growth were studied by light microscope. Chromium has been regarded as an essential trace element for life. However, hexavalent chromium is a known carcinogen, mutagen, cytotoxicant and strong oxidizing agent. Cr(VI) of different concentration have different effects on T thermophila BF5 growth with the phenomenon of low dose stimulation (0-3 x 10(-5) mol L-1) and high dose inhibition (3 x 10(-5) to 2.4 x 10(-4) mol L-1). The relationship between the growth rate constant (k) and c is a typical U-shaped curve, which is a characteristic of hormesis. T thermophila BF5 cannot grow at all when the concentration of Cr(VI) is up to 2.4 x 10(-4) mol L-1. The microscopic observations agree well with the results obtained by means of microcalorimetry. And T thermophila BF5 had obviously morphological changes by the addition of Cr(VI). (c) 2006 Elsevier B.V. All rights reserved.; Tetrahymena thermophila BF5 produce heat by metabolism and movement. Using a TAM air isothermal microcalorimeter, the power-time curves of the metabolism of T thermophila BF5 during growth were obtained and the action on them by the addition of Cr(VI) were studied. The morphological change with Cr(VI) coexisted and biomass change during the process of T thermophila BF5 growth were studied by light microscope. Chromium has been regarded as an essential trace element for life. However, hexavalent chromium is a known carcinogen, mutagen, cytotoxicant and strong oxidizing agent. Cr(VI) of different concentration have different effects on T thermophila BF5 growth with the phenomenon of low dose stimulation (0-3 x 10(-5) mol L-1) and high dose inhibition (3 x 10(-5) to 2.4 x 10(-4) mol L-1). The relationship between the growth rate constant (k) and c is a typical U-shaped curve, which is a characteristic of hormesis. T thermophila BF5 cannot grow at all when the concentration of Cr(VI) is up to 2.4 x 10(-4) mol L-1. The microscopic observations agree well with the results obtained by means of microcalorimetry. And T thermophila BF5 had obviously morphological changes by the addition of Cr(VI). (c) 2006 Elsevier B.V. All rights reserved.
SubtypeArticle
Keywordt Thermophila Bf5 Microcalorimetry Morphological Change Toxicology Growth Metabolism
DepartmentWuhan Univ, Coll Chem & Mol Sci, Dept Biol Chem, Wuhan 430072, Peoples R China; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Subject AreaEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
DOI10.1016/j.etap.2005.12.011
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000239683900001
WOS KeywordIN-VITRO ; PYRIFORMIS ; CHROMIUM ; CHROMATE ; HORMESIS ; CYTOTOXICITY ; BIOASSAY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/8884
Collection期刊论文
Corresponding AuthorLiu, Y, Wuhan Univ, Coll Chem & Mol Sci, Dept Biol Chem, Wuhan 430072, Peoples R China
Affiliation1.Wuhan Univ, Coll Chem & Mol Sci, Dept Biol Chem, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Dan,Liu, Yi,Zhang, Yue,et al. Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2006,22(2):121-127.
APA Zheng, Dan,Liu, Yi,Zhang, Yue,Chen, Xiao-Juan,Shen, Yun-Fen,&Liu, Y, Wuhan Univ, Coll Chem & Mol Sci, Dept Biol Chem, Wuhan 430072, Peoples R China.(2006).Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,22(2),121-127.
MLA Zheng, Dan,et al."Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 22.2(2006):121-127.
Files in This Item:
File Name/Size DocType Version Access License
Microcalorimetric in(329KB) 开放获取--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zheng, Dan]'s Articles
[Liu, Yi]'s Articles
[Zhang, Yue]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zheng, Dan]'s Articles
[Liu, Yi]'s Articles
[Zhang, Yue]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zheng, Dan]'s Articles
[Liu, Yi]'s Articles
[Zhang, Yue]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.