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学科主题: Environmental Sciences; Pharmacology & Pharmacy; Toxicology
题名: Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth
作者: Zheng, Dan; Liu, Yi; Zhang, Yue; Chen, Xiao-Juan; Shen, Yun-Fen
通讯作者: Liu, Y, Wuhan Univ, Coll Chem & Mol Sci, Dept Biol Chem, Wuhan 430072, Peoples R China
关键词: T thermophila BF5 ; microcalorimetry ; morphological change ; toxicology ; growth metabolism
刊名: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
发表日期: 2006-09-01
DOI: 10.1016/j.etap.2005.12.011
卷: 22, 期:2, 页:121-127
收录类别: SCI
文章类型: Article
部门归属: Wuhan Univ, Coll Chem & Mol Sci, Dept Biol Chem, Wuhan 430072, Peoples R China; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
摘要: Tetrahymena thermophila BF5 produce heat by metabolism and movement. Using a TAM air isothermal microcalorimeter, the power-time curves of the metabolism of T thermophila BF5 during growth were obtained and the action on them by the addition of Cr(VI) were studied. The morphological change with Cr(VI) coexisted and biomass change during the process of T thermophila BF5 growth were studied by light microscope. Chromium has been regarded as an essential trace element for life. However, hexavalent chromium is a known carcinogen, mutagen, cytotoxicant and strong oxidizing agent. Cr(VI) of different concentration have different effects on T thermophila BF5 growth with the phenomenon of low dose stimulation (0-3 x 10(-5) mol L-1) and high dose inhibition (3 x 10(-5) to 2.4 x 10(-4) mol L-1). The relationship between the growth rate constant (k) and c is a typical U-shaped curve, which is a characteristic of hormesis. T thermophila BF5 cannot grow at all when the concentration of Cr(VI) is up to 2.4 x 10(-4) mol L-1. The microscopic observations agree well with the results obtained by means of microcalorimetry. And T thermophila BF5 had obviously morphological changes by the addition of Cr(VI). (c) 2006 Elsevier B.V. All rights reserved.
英文摘要: Tetrahymena thermophila BF5 produce heat by metabolism and movement. Using a TAM air isothermal microcalorimeter, the power-time curves of the metabolism of T thermophila BF5 during growth were obtained and the action on them by the addition of Cr(VI) were studied. The morphological change with Cr(VI) coexisted and biomass change during the process of T thermophila BF5 growth were studied by light microscope. Chromium has been regarded as an essential trace element for life. However, hexavalent chromium is a known carcinogen, mutagen, cytotoxicant and strong oxidizing agent. Cr(VI) of different concentration have different effects on T thermophila BF5 growth with the phenomenon of low dose stimulation (0-3 x 10(-5) mol L-1) and high dose inhibition (3 x 10(-5) to 2.4 x 10(-4) mol L-1). The relationship between the growth rate constant (k) and c is a typical U-shaped curve, which is a characteristic of hormesis. T thermophila BF5 cannot grow at all when the concentration of Cr(VI) is up to 2.4 x 10(-4) mol L-1. The microscopic observations agree well with the results obtained by means of microcalorimetry. And T thermophila BF5 had obviously morphological changes by the addition of Cr(VI). (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: IN-VITRO ; PYRIFORMIS ; CHROMIUM ; CHROMATE ; HORMESIS ; CYTOTOXICITY ; BIOASSAY
语种: 英语
WOS记录号: WOS:000239683900001
ISSN号: 1382-6689
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/8884
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Wuhan Univ, Coll Chem & Mol Sci, Dept Biol Chem, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China

Recommended Citation:
Zheng, Dan; Liu, Yi; Zhang, Yue; Chen, Xiao-Juan; Shen, Yun-Fen.Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth,ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2006,22(2):121-127
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