IHB OpenIR  > 期刊论文
Microcystin-RR-induced apoptosis in tobacco BY-2 cells
Yin, Liyan; Huang, Jiaquan; Li, Wei; Liu, Yongding; Liu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2006-08-01
Source PublicationTOXICON
ISSN0041-0101
Volume48Issue:2Pages:204-210
AbstractOur previous studies showed that microcystin-RR could induce oxidative damage in plant cells as they do with animal cells. However, whether microcystin can induce plant cell apoptosis is still unknown. In this study, the morphological changes of tobacco BY-2 suspension cells exposed to microcystin-RR were observed under light microscopy and transmission electron microscopy, and apoptosis was clearly distinguished by intense perinuclear chromatin margination, condensation of nuclear chromatin after 6d exposure of 50 mg/L (about 50 mu M) microcystin-RR. We also found that microcystin-RR can induce tobacco cell apoptosis in a dose- and time-dependent manner with flow cytometry analysis. Our study provides the first evidence that microcystins can induce plant cell apoptosis. (c) 2006 Elsevier Ltd. All rights reserved.; Our previous studies showed that microcystin-RR could induce oxidative damage in plant cells as they do with animal cells. However, whether microcystin can induce plant cell apoptosis is still unknown. In this study, the morphological changes of tobacco BY-2 suspension cells exposed to microcystin-RR were observed under light microscopy and transmission electron microscopy, and apoptosis was clearly distinguished by intense perinuclear chromatin margination, condensation of nuclear chromatin after 6d exposure of 50 mg/L (about 50 mu M) microcystin-RR. We also found that microcystin-RR can induce tobacco cell apoptosis in a dose- and time-dependent manner with flow cytometry analysis. Our study provides the first evidence that microcystins can induce plant cell apoptosis. (c) 2006 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordMicrocystin-rr Tobacco By-2 Cells Apoptosis Flow Cytometry Transmission Electron Microscopy
DepartmentChinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; Chinese Acad Sci, Bot Gardens, Wuhan 430072, Peoples R China; Chinese Acad Agr Sci, Oil Crops Res Inst, Wuhan 430062, Peoples R China
Subject AreaPharmacology & Pharmacy ; Toxicology
DOI10.1016/j.toxicon.2006.05.002
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS IDWOS:000240050500008
WOS KeywordCYANOBACTERIAL TOXIN ; PROTEIN PHOSPHATASES ; LR ; INHIBITION ; HEPATOCYTES ; TOXICITY ; GROWTH ; PLANTS
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/8856
Collection期刊论文
Corresponding AuthorLiu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Bot Gardens, Wuhan 430072, Peoples R China
3.Chinese Acad Agr Sci, Oil Crops Res Inst, Wuhan 430062, Peoples R China
Recommended Citation
GB/T 7714
Yin, Liyan,Huang, Jiaquan,Li, Wei,et al. Microcystin-RR-induced apoptosis in tobacco BY-2 cells[J]. TOXICON,2006,48(2):204-210.
APA Yin, Liyan,Huang, Jiaquan,Li, Wei,Liu, Yongding,&Liu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.(2006).Microcystin-RR-induced apoptosis in tobacco BY-2 cells.TOXICON,48(2),204-210.
MLA Yin, Liyan,et al."Microcystin-RR-induced apoptosis in tobacco BY-2 cells".TOXICON 48.2(2006):204-210.
Files in This Item:
File Name/Size DocType Version Access License
Microcystin-RR-induc(644KB) 开放获取--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yin, Liyan]'s Articles
[Huang, Jiaquan]'s Articles
[Li, Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yin, Liyan]'s Articles
[Huang, Jiaquan]'s Articles
[Li, Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yin, Liyan]'s Articles
[Huang, Jiaquan]'s Articles
[Li, Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Microcystin-RR-induced apoptosis in tobacco BY-2 cells.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.