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Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)
Song, S. B.; Xu, Y.; Zhou, B. S.; Xu, Y, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu S Rd 7, Wuhan 430072, Peoples R China
2006-10-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume65Issue:4Pages:699-706
AbstractHexachlorobenzene (HCB)-induced oxidative damages have been published in rats while the effects have not yet been reported in fishes. Juvenile common carps (Cyprinus carpio) were exposed to waterborne HCB from 2 to 200 mu g l(-1) for 5, 10 or 20 days. Liver and brain were analyzed for various parameters of oxidative stress. There were no significant changes of glutathione (GSH) content and superoxide dismutase (SOD) activity in liver after 5 or 10 days exposure, whereas obvious drops were observed at higher concentrations after 20 days exposure. Significant decreases of GSH content and SOD activity in brain were found during all the exposure days. In brain, HCB also significantly elevated the contents of reactive oxygen species (ROS), thiobarbituric acid-reactive substances (TBARS, as an indicator of lipid peroxidation products), glutathione disulfide (GSSG), and activities of nitric oxide synthase (NOS), glutathione peroxidase (GPx), and glutathione reductase (GR), and inhibited activities of acetylcholinesterase (AchE) and glutathione S-transferase (GST). The results clearly demonstrated that environmentally possible level of HCB could result in oxidative stress in fish and brain was a sensitive target organ of HCB toxicity. (c) 2006 Elsevier Ltd. All rights reserved.; Hexachlorobenzene (HCB)-induced oxidative damages have been published in rats while the effects have not yet been reported in fishes. Juvenile common carps (Cyprinus carpio) were exposed to waterborne HCB from 2 to 200 mu g l(-1) for 5, 10 or 20 days. Liver and brain were analyzed for various parameters of oxidative stress. There were no significant changes of glutathione (GSH) content and superoxide dismutase (SOD) activity in liver after 5 or 10 days exposure, whereas obvious drops were observed at higher concentrations after 20 days exposure. Significant decreases of GSH content and SOD activity in brain were found during all the exposure days. In brain, HCB also significantly elevated the contents of reactive oxygen species (ROS), thiobarbituric acid-reactive substances (TBARS, as an indicator of lipid peroxidation products), glutathione disulfide (GSSG), and activities of nitric oxide synthase (NOS), glutathione peroxidase (GPx), and glutathione reductase (GR), and inhibited activities of acetylcholinesterase (AchE) and glutathione S-transferase (GST). The results clearly demonstrated that environmentally possible level of HCB could result in oxidative stress in fish and brain was a sensitive target organ of HCB toxicity. (c) 2006 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordAcetylcholinesterase Antioxidant Enzymes Glutathione Lipid Peroxidation (Lpo) Oxidative Stress Reactive Oxygen Species
DepartmentChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Subject AreaEnvironmental Sciences
DOI10.1016/j.chemosphere.2006.01.033
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000241652000022
WOS KeywordFRESH-WATER FISH ; GLUTATHIONE S-TRANSFERASES ; OXYGEN SPECIES PRODUCTION ; OXIDATIVE STRESS ; RAT-BRAIN ; EXPOSURE ; ENZYMES ; METABOLISM ; INDUCTION ; PORPHYRIA
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/8806
Collection期刊论文
Corresponding AuthorXu, Y, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu S Rd 7, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Song, S. B.,Xu, Y.,Zhou, B. S.,et al. Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)[J]. CHEMOSPHERE,2006,65(4):699-706.
APA Song, S. B.,Xu, Y.,Zhou, B. S.,&Xu, Y, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu S Rd 7, Wuhan 430072, Peoples R China.(2006).Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio).CHEMOSPHERE,65(4),699-706.
MLA Song, S. B.,et al."Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)".CHEMOSPHERE 65.4(2006):699-706.
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