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Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography
Wen Yi; Wang Ying; Zhou Bing-Sheng; Xu Ying; Feng Yu-Qi; Feng, YQ, Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
2007-05-01
Source PublicationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
Volume35Issue:5Pages:681-684
AbstractA method was presented for the determination of testosterone, methyltestosterone and progesterone in liquid cosmetics by coupling polymer monolith microextraction (PMME) to high performance liquid chromatography with UV detection. A poly (methacrylic acid-ethylene glycol dimethacrylate) monolithic capillary column was selected as the extraction medium, which showed high extraction capacity towards these compounds. To achieve optimum extraction performance, several parameters relating to PMME were investigated, including extraction flow rate and pH value, inorganic salt and organic phase concentration of the sample matrix. By simple dilution with phosphate solution and filtering, the sample solution then could be directly injected into the device for extraction. The limits of detection of testosterone, methyltestosterone and progesterone were calculated to be 2, 3, 2, 8 and 4.6 mu g/L. Good linearity was achieved in the range of 10 to 1000 mu g/L with a linear coefficient. r value above 0. 996. Excellent method reproducibility was found by intra- and inter-day precisions, yielding the relative standard deviations of < 7. 7 % and < 7. 5 %, respectively. Recovery for them in the real samples was between 83% and 119%.; A method was presented for the determination of testosterone, methyltestosterone and progesterone in liquid cosmetics by coupling polymer monolith microextraction (PMME) to high performance liquid chromatography with UV detection. A poly (methacrylic acid-ethylene glycol dimethacrylate) monolithic capillary column was selected as the extraction medium, which showed high extraction capacity towards these compounds. To achieve optimum extraction performance, several parameters relating to PMME were investigated, including extraction flow rate and pH value, inorganic salt and organic phase concentration of the sample matrix. By simple dilution with phosphate solution and filtering, the sample solution then could be directly injected into the device for extraction. The limits of detection of testosterone, methyltestosterone and progesterone were calculated to be 2, 3, 2, 8 and 4.6 mu g/L. Good linearity was achieved in the range of 10 to 1000 mu g/L with a linear coefficient. r value above 0. 996. Excellent method reproducibility was found by intra- and inter-day precisions, yielding the relative standard deviations of < 7. 7 % and < 7. 5 %, respectively. Recovery for them in the real samples was between 83% and 119%.
SubtypeArticle
KeywordPolymer Monolith Microextraction High Performance Liquid Chromatography Sexual Hormones Liquid Cosmetics
DepartmentWuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China; Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Subject AreaChemistry ; Analytical
WOS HeadingsScience & Technology ; Physical Sciences
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000246993300013
WOS KeywordSOLID-PHASE MICROEXTRACTION ; CAPILLARY ; DRUGS
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Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/8566
Collection期刊论文
Corresponding AuthorFeng, YQ, Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
Affiliation1.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Wen Yi,Wang Ying,Zhou Bing-Sheng,et al. Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2007,35(5):681-684.
APA Wen Yi,Wang Ying,Zhou Bing-Sheng,Xu Ying,Feng Yu-Qi,&Feng, YQ, Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China.(2007).Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,35(5),681-684.
MLA Wen Yi,et al."Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 35.5(2007):681-684.
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