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学科主题: Chemistry ; Analytical
题名: Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography
作者: Wen Yi; Wang Ying; Zhou Bing-Sheng; Xu Ying; Feng Yu-Qi
通讯作者: Feng, YQ, Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
关键词: polymer monolith microextraction ; high performance liquid chromatography ; sexual hormones ; liquid cosmetics
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2007-05-01
卷: 35, 期:5, 页:681-684
收录类别: SCI
文章类型: Article
部门归属: Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China; Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
摘要: A method was presented for the determination of testosterone, methyltestosterone and progesterone in liquid cosmetics by coupling polymer monolith microextraction (PMME) to high performance liquid chromatography with UV detection. A poly (methacrylic acid-ethylene glycol dimethacrylate) monolithic capillary column was selected as the extraction medium, which showed high extraction capacity towards these compounds. To achieve optimum extraction performance, several parameters relating to PMME were investigated, including extraction flow rate and pH value, inorganic salt and organic phase concentration of the sample matrix. By simple dilution with phosphate solution and filtering, the sample solution then could be directly injected into the device for extraction. The limits of detection of testosterone, methyltestosterone and progesterone were calculated to be 2, 3, 2, 8 and 4.6 mu g/L. Good linearity was achieved in the range of 10 to 1000 mu g/L with a linear coefficient. r value above 0. 996. Excellent method reproducibility was found by intra- and inter-day precisions, yielding the relative standard deviations of < 7. 7 % and < 7. 5 %, respectively. Recovery for them in the real samples was between 83% and 119%.
英文摘要: A method was presented for the determination of testosterone, methyltestosterone and progesterone in liquid cosmetics by coupling polymer monolith microextraction (PMME) to high performance liquid chromatography with UV detection. A poly (methacrylic acid-ethylene glycol dimethacrylate) monolithic capillary column was selected as the extraction medium, which showed high extraction capacity towards these compounds. To achieve optimum extraction performance, several parameters relating to PMME were investigated, including extraction flow rate and pH value, inorganic salt and organic phase concentration of the sample matrix. By simple dilution with phosphate solution and filtering, the sample solution then could be directly injected into the device for extraction. The limits of detection of testosterone, methyltestosterone and progesterone were calculated to be 2, 3, 2, 8 and 4.6 mu g/L. Good linearity was achieved in the range of 10 to 1000 mu g/L with a linear coefficient. r value above 0. 996. Excellent method reproducibility was found by intra- and inter-day precisions, yielding the relative standard deviations of < 7. 7 % and < 7. 5 %, respectively. Recovery for them in the real samples was between 83% and 119%.
关键词[WOS]: SOLID-PHASE MICROEXTRACTION ; CAPILLARY ; DRUGS
语种: 英语
WOS记录号: WOS:000246993300013
ISSN号: 0253-3820
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/8566
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

Recommended Citation:
Wen Yi; Wang Ying; Zhou Bing-Sheng; Xu Ying; Feng Yu-Qi.Determination of sexual hormones in liquid cosmetics by polymer monolith microextraction coupled with high performance liquid chromatography,CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2007,35(5):681-684
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