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Effects of microcystin-RR on the antioxidant system of Bacillus subtilis
Yang, Cui-Yun1,2; Liu, Yong-Ding1; Li, Dun-Hai1; Liu, YD, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2007
Source PublicationFRESENIUS ENVIRONMENTAL BULLETIN
ISSN1018-4619
Volume16Issue:11BPages:1435-1441
AbstractMicrocystins are a kind of cyclic hepatotoxins produced by many cyanobacterial species. Many works have been done concerning, the toxic effects of microcystins on animals and plants. However, the reports about their effects on microbial cells are very limited. In the present paper, Bacillus subtilis (B. subtilis) was used to determine the dose- and time-effect of microcystin-RR, and the results showed that the activity of antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT) was significantly increased to that of control, when exposed to 5 or 10 mu g/ml microcystin-RR for 1 h. The contents of thiobarbituric acid-reactive sub-stances (TBARS) and glutathione (GSH) as well as glu-tathione reductase (GR) activity were obviously increased only when exposed to 10 mu g/ml microcystin-RR. For the time-effect of microcystin-RR on B. subtilis, the activities of antioxidant enzymes including SOD and CAT as well as GR activity and TBARS, GSH contents in B. subtilis were at first significantly increased, and then subsequently de-creased. These results suggested that microcystin-RR could induce the oxidative stress of B. subtilis for a short period. The antioxidant system protects B. subtilis from oxidative damage.; Microcystins are a kind of cyclic hepatotoxins produced by many cyanobacterial species. Many works have been done concerning, the toxic effects of microcystins on animals and plants. However, the reports about their effects on microbial cells are very limited. In the present paper, Bacillus subtilis (B. subtilis) was used to determine the dose- and time-effect of microcystin-RR, and the results showed that the activity of antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT) was significantly increased to that of control, when exposed to 5 or 10 mu g/ml microcystin-RR for 1 h. The contents of thiobarbituric acid-reactive sub-stances (TBARS) and glutathione (GSH) as well as glu-tathione reductase (GR) activity were obviously increased only when exposed to 10 mu g/ml microcystin-RR. For the time-effect of microcystin-RR on B. subtilis, the activities of antioxidant enzymes including SOD and CAT as well as GR activity and TBARS, GSH contents in B. subtilis were at first significantly increased, and then subsequently de-creased. These results suggested that microcystin-RR could induce the oxidative stress of B. subtilis for a short period. The antioxidant system protects B. subtilis from oxidative damage.
SubtypeArticle
KeywordMicrocystin-rr Bacillus Subtilis Superoxide Dismutase Catalase Glutathione Oxidative Stress
Department[Yang, Cui-Yun; Liu, Yong-Ding; Li, Dun-Hai] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Yang, Cui-Yun] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Subject AreaEnvironmental Sciences
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000252003500003
WOS KeywordLYMPHOCYTES IN-VITRO ; SUPEROXIDE-DISMUTASE ; ESCHERICHIA-COLI ; LR ; GLUTATHIONE ; GROWTH ; CYANOBACTERIUM ; ACCUMULATION ; AERUGINOSA ; BACTERIAL
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/8318
Collection期刊论文
Corresponding AuthorLiu, YD, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Yang, Cui-Yun,Liu, Yong-Ding,Li, Dun-Hai,et al. Effects of microcystin-RR on the antioxidant system of Bacillus subtilis[J]. FRESENIUS ENVIRONMENTAL BULLETIN,2007,16(11B):1435-1441.
APA Yang, Cui-Yun,Liu, Yong-Ding,Li, Dun-Hai,&Liu, YD, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2007).Effects of microcystin-RR on the antioxidant system of Bacillus subtilis.FRESENIUS ENVIRONMENTAL BULLETIN,16(11B),1435-1441.
MLA Yang, Cui-Yun,et al."Effects of microcystin-RR on the antioxidant system of Bacillus subtilis".FRESENIUS ENVIRONMENTAL BULLETIN 16.11B(2007):1435-1441.
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