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学科主题: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity
题名: U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia
作者: Xiao, W.2, 3; Zhang, Q.2; Habermacher, G.2; Yang, X.4, 5; Zhang, A-y1, 2; Cai, X.2; Hahn, J.2; Liu, J.1; Pins, M.4, 5; Doglio, L.6; Dhir, R.7; Gingrich, J.1; Wang, Z.1, 2, 5, 6
通讯作者: Wang, Z, Univ Pittsburgh, Dept Urol, Shadyside Med Ctr, Inst Canc,Sch Med, Suite G40,5200 Ctr Ave, Pittsburgh, PA 15232 USA
关键词: U19/Eaf2 ; lung adenocarcinoma ; B-cell lymphoma ; hepatocellular carcinoma ; prostate cancer ; tumor suppressor
刊名: ONCOGENE
发表日期: 2008-03-06
DOI: 10.1038/sj.onc.1210786
卷: 27, 期:11, 页:1536-1544
收录类别: SCI
文章类型: Article
部门归属: [Zhang, A-y; Liu, J.; Gingrich, J.; Wang, Z.] Univ Pittsburgh, Dept Urol, Shadyside Med Ctr, Inst Canc,Sch Med, Pittsburgh, PA 15232 USA; [Xiao, W.; Zhang, Q.; Habermacher, G.; Zhang, A-y; Cai, X.; Hahn, J.; Wang, Z.] Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA; [Xiao, W.] Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China; [Yang, X.; Pins, M.] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA; [Yang, X.; Pins, M.; Wang, Z.] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA; [Doglio, L.; Wang, Z.] Northwestern Univ, Feinberg Sch Med, Ctr Genet Med, Chicago, IL 60611 USA; [Dhir, R.] Univ Pittsburgh, Sch Med, Dept Pathol, Inst Canc, Pittsburgh, PA USA
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
摘要: Upregulated gene 19 (U19)/ELL-associated factor 2 (Eaf2) is a potential human tumor suppressor that exhibits frequent allelic loss and downregulation in high-grade prostate cancer. U19/Eaf2, along with its homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the eleven-nineteen lysine-rich leukemia (ELL) family of proteins. To further explore the tumor-suppressive effects of U19/Eaf2, we constructed and characterized a murine U19/Eaf2-knockout model. Homozygous or heterozygous deletion of U19/Eaf2 resulted in high rates of lung adenocarcinoma, B-cell lymphoma, hepato cellular carcinoma and prostate intraepithelial neoplasia. Within the mouse prostate, U19/Eaf2 defficiency enhanced cell proliferation and increased epithelial cell size. The knockout mice also exhibited cardiac cell hypertrophy. These data indicate a role for U19/Eaf2 in growth suppression and cell size control as well as argue for U19/Eaf2 as a novel tumor suppressor in multiple mouse tissues. The U19/Eaf2 knockout mouse also provides a unique animal model for three important cancers: lung adenocarcinoma, B-cell lymphoma and hepatocellular carcinoma.
英文摘要: Upregulated gene 19 (U19)/ELL-associated factor 2 (Eaf2) is a potential human tumor suppressor that exhibits frequent allelic loss and downregulation in high-grade prostate cancer. U19/Eaf2, along with its homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the eleven-nineteen lysine-rich leukemia (ELL) family of proteins. To further explore the tumor-suppressive effects of U19/Eaf2, we constructed and characterized a murine U19/Eaf2-knockout model. Homozygous or heterozygous deletion of U19/Eaf2 resulted in high rates of lung adenocarcinoma, B-cell lymphoma, hepato cellular carcinoma and prostate intraepithelial neoplasia. Within the mouse prostate, U19/Eaf2 defficiency enhanced cell proliferation and increased epithelial cell size. The knockout mice also exhibited cardiac cell hypertrophy. These data indicate a role for U19/Eaf2 in growth suppression and cell size control as well as argue for U19/Eaf2 as a novel tumor suppressor in multiple mouse tissues. The U19/Eaf2 knockout mouse also provides a unique animal model for three important cancers: lung adenocarcinoma, B-cell lymphoma and hepatocellular carcinoma.
关键词[WOS]: ELONGATION-FACTOR ELL ; TUMOR-SUPPRESSOR ; VASCULAR TUMORS ; FACTOR-2 EAF2 ; CAJAL BODY ; GENE ; POLYMERASE ; MLL ; INACTIVATION ; EXPRESSION
语种: 英语
WOS记录号: WOS:000253815800005
ISSN号: 0950-9232
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/8228
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Univ Pittsburgh, Dept Urol, Shadyside Med Ctr, Inst Canc,Sch Med, Pittsburgh, PA 15232 USA
2.Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA
3.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
4.Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA
5.Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
6.Northwestern Univ, Feinberg Sch Med, Ctr Genet Med, Chicago, IL 60611 USA
7.Univ Pittsburgh, Sch Med, Dept Pathol, Inst Canc, Pittsburgh, PA USA

Recommended Citation:
Xiao, W.; Zhang, Q.; Habermacher, G.; Yang, X.; Zhang, A-y; Cai, X.; Hahn, J.; Liu, J.; Pins, M.; Doglio, L.; Dhir, R.; Gingrich, J.; Wang, Z..U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia,ONCOGENE,2008,27(11):1536-1544
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