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Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)
Zhang, Xuezhen2; Xie, Ping1,2; Wang, Weimin2; Li, Dapeng1,2; Li, Li1,2; Tang, Rong1,2; Lei, Hehua1; Shi, Zechao3; Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2008-03-01
Source PublicationTOXICON
ISSN0041-0101
Volume51Issue:3Pages:449-456
AbstractA laboratory toxic experiment was conducted to examine dose-dependent effects of extracted microcystins (MCs) on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis). Fertilized eggs were incubated in solutions with four concentrations of MCs (0, 1, 10, 100 mu g MC-LReq l(-1)). Higher MCs retarded egg development (2-10 h delays) and larval growth, reduced hatching rate (up to 45%), and caused high malformation rate (up to 15%) and hepatocytes damage (characterized by disorganization of cell structure and a loss of adherence between hepatocytes, cellular degeneration with vacuolar hepatocytes and marginal nuclei, even hepatocellular necrosis). A 10 mu g MC-LReql(-1) is close to a high concentration in natural cyanobacterial blooms, suggesting a possible existence of such toxic effects in eutrophic waters. (c) 2007 Elsevier Ltd. All rights reserved.; A laboratory toxic experiment was conducted to examine dose-dependent effects of extracted microcystins (MCs) on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis). Fertilized eggs were incubated in solutions with four concentrations of MCs (0, 1, 10, 100 mu g MC-LReq l(-1)). Higher MCs retarded egg development (2-10 h delays) and larval growth, reduced hatching rate (up to 45%), and caused high malformation rate (up to 15%) and hepatocytes damage (characterized by disorganization of cell structure and a loss of adherence between hepatocytes, cellular degeneration with vacuolar hepatocytes and marginal nuclei, even hepatocellular necrosis). A 10 mu g MC-LReql(-1) is close to a high concentration in natural cyanobacterial blooms, suggesting a possible existence of such toxic effects in eutrophic waters. (c) 2007 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordMicrocystins Crude Extract Southern Catfish Embryonic Development Larval Growth Histopathological Changes
Department[Xie, Ping; Li, Dapeng; Li, Li; Tang, Rong; Lei, Hehua] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; [Zhang, Xuezhen; Xie, Ping; Wang, Weimin; Li, Dapeng; Li, Li; Tang, Rong] Huazhong Agr Univ, Minist Educ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China; [Shi, Zechao] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Jinzhou 434000, Peoples R China
Subject AreaPharmacology & Pharmacy ; Toxicology
DOI10.1016/j.toxicon.2007.11.005
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS IDWOS:000254369600014
WOS KeywordCARP CYPRINUS-CARPIO ; ZEBRAFISH DANIO-RERIO ; CYANOBACTERIAL TOXINS ; CARASSIUS-AURATUS ; ORYZIAS-LATIPES ; CRUDE EXTRACTS ; LR ; FISH ; TOXICITY ; ACCUMULATION
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/8202
Collection期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Minist Educ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China
3.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Jinzhou 434000, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xuezhen,Xie, Ping,Wang, Weimin,et al. Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)[J]. TOXICON,2008,51(3):449-456.
APA Zhang, Xuezhen.,Xie, Ping.,Wang, Weimin.,Li, Dapeng.,Li, Li.,...&Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China.(2008).Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis).TOXICON,51(3),449-456.
MLA Zhang, Xuezhen,et al."Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)".TOXICON 51.3(2008):449-456.
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