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学科主题: Pharmacology & Pharmacy; Toxicology
题名: Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)
作者: Zhang, Xuezhen2; Xie, Ping1, 2; Wang, Weimin2; Li, Dapeng1, 2; Li, Li1, 2; Tang, Rong1, 2; Lei, Hehua1; Shi, Zechao3
通讯作者: Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
关键词: microcystins ; crude extract ; southern catfish ; embryonic development ; larval growth ; histopathological changes
刊名: TOXICON
发表日期: 2008-03-01
DOI: 10.1016/j.toxicon.2007.11.005
卷: 51, 期:3, 页:449-456
收录类别: SCI
文章类型: Article
部门归属: [Xie, Ping; Li, Dapeng; Li, Li; Tang, Rong; Lei, Hehua] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; [Zhang, Xuezhen; Xie, Ping; Wang, Weimin; Li, Dapeng; Li, Li; Tang, Rong] Huazhong Agr Univ, Minist Educ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China; [Shi, Zechao] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Jinzhou 434000, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
摘要: A laboratory toxic experiment was conducted to examine dose-dependent effects of extracted microcystins (MCs) on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis). Fertilized eggs were incubated in solutions with four concentrations of MCs (0, 1, 10, 100 mu g MC-LReq l(-1)). Higher MCs retarded egg development (2-10 h delays) and larval growth, reduced hatching rate (up to 45%), and caused high malformation rate (up to 15%) and hepatocytes damage (characterized by disorganization of cell structure and a loss of adherence between hepatocytes, cellular degeneration with vacuolar hepatocytes and marginal nuclei, even hepatocellular necrosis). A 10 mu g MC-LReql(-1) is close to a high concentration in natural cyanobacterial blooms, suggesting a possible existence of such toxic effects in eutrophic waters. (c) 2007 Elsevier Ltd. All rights reserved.
英文摘要: A laboratory toxic experiment was conducted to examine dose-dependent effects of extracted microcystins (MCs) on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis). Fertilized eggs were incubated in solutions with four concentrations of MCs (0, 1, 10, 100 mu g MC-LReq l(-1)). Higher MCs retarded egg development (2-10 h delays) and larval growth, reduced hatching rate (up to 45%), and caused high malformation rate (up to 15%) and hepatocytes damage (characterized by disorganization of cell structure and a loss of adherence between hepatocytes, cellular degeneration with vacuolar hepatocytes and marginal nuclei, even hepatocellular necrosis). A 10 mu g MC-LReql(-1) is close to a high concentration in natural cyanobacterial blooms, suggesting a possible existence of such toxic effects in eutrophic waters. (c) 2007 Elsevier Ltd. All rights reserved.
关键词[WOS]: CARP CYPRINUS-CARPIO ; ZEBRAFISH DANIO-RERIO ; CYANOBACTERIAL TOXINS ; CARASSIUS-AURATUS ; ORYZIAS-LATIPES ; CRUDE EXTRACTS ; LR ; FISH ; TOXICITY ; ACCUMULATION
语种: 英语
WOS记录号: WOS:000254369600014
ISSN号: 0041-0101
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/8202
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Minist Educ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China
3.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Jinzhou 434000, Peoples R China

Recommended Citation:
Zhang, Xuezhen; Xie, Ping; Wang, Weimin; Li, Dapeng; Li, Li; Tang, Rong; Lei, Hehua; Shi, Zechao.Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis),TOXICON,2008,51(3):449-456
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