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学科主题: Environmental Sciences; Toxicology
题名: Distribution of toxins in various tissues of crucian carp intraperitoneally injected with hepatotoxic microcystins
作者: Lei, Hehua1; Xie, Ping1; Chen, Jun1; Liang, Gaodao1; Dai, Ming1; Zhang, Xuezhen2
通讯作者: Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China
关键词: microcystins ; intraperitoneal injection ; Crucian carp ; tissue distribution ; depuration
刊名: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
发表日期: 2008-05-01
卷: 27, 期:5, 页:1167-1174
收录类别: SCI
文章类型: Article
部门归属: [Lei, Hehua; Xie, Ping; Chen, Jun; Liang, Gaodao; Dai, Ming] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China; [Zhang, Xuezhen] Huazhong Agr Univ, Coll Fisheries, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Toxicology
摘要: An acute toxicity experiment was conducted to examine the distribution and depuration of microcystins (MCS) in crucian carp (Carassius aurutus) tissues. Fish were injected intraperitoneally with extracted MCs at a dose of 200 mu g MC-LR (where L = leucine and R = arginine) equivalent/kg body weight. Microcystin concentrations in various tissues and aquaria water were analyzed at 1, 3, 12, 24, and 48 h postinjection using liquid chromatography coupled with mass spectrometry. Microcystins were detected mainly in blood (3.99% of injected dose at 1 h), liver (1.60% at I h), gonad (1.49% at 3 h), and kidney (0.14% at 48 h). Other tissues, such as the heart, gill, gallbladder, intestine, spleen, brain, and muscle, contained less than 0.1% of the injected MCs. The highest concentration of MCs was found in blood (526-3,753 ng/g dry wt), followed by liver (103-1,656 ng/g dry wt) and kidney (279-1,592 ng/g dry wt). No MC-LR was detectable in intestine, spleen, kidney, brain, and muscle, whereas MC-RR was found in all examined fish tissues, which might result from organ specificity of different MCs. Clearance of MC-RR in brain tissue was slow. In kidney, the MC-RR content was negatively correlated with that in blood, suggesting that blood was important in the transportation of MC-RR to kidney for excretion.
英文摘要: An acute toxicity experiment was conducted to examine the distribution and depuration of microcystins (MCS) in crucian carp (Carassius aurutus) tissues. Fish were injected intraperitoneally with extracted MCs at a dose of 200 mu g MC-LR (where L = leucine and R = arginine) equivalent/kg body weight. Microcystin concentrations in various tissues and aquaria water were analyzed at 1, 3, 12, 24, and 48 h postinjection using liquid chromatography coupled with mass spectrometry. Microcystins were detected mainly in blood (3.99% of injected dose at 1 h), liver (1.60% at I h), gonad (1.49% at 3 h), and kidney (0.14% at 48 h). Other tissues, such as the heart, gill, gallbladder, intestine, spleen, brain, and muscle, contained less than 0.1% of the injected MCs. The highest concentration of MCs was found in blood (526-3,753 ng/g dry wt), followed by liver (103-1,656 ng/g dry wt) and kidney (279-1,592 ng/g dry wt). No MC-LR was detectable in intestine, spleen, kidney, brain, and muscle, whereas MC-RR was found in all examined fish tissues, which might result from organ specificity of different MCs. Clearance of MC-RR in brain tissue was slow. In kidney, the MC-RR content was negatively correlated with that in blood, suggesting that blood was important in the transportation of MC-RR to kidney for excretion.
关键词[WOS]: TROUT ONCORHYNCHUS-MYKISS ; PHYTOPLANKTIVOROUS SILVER CARP ; FRESH-WATER SNAIL ; RAINBOW-TROUT ; EUTROPHIC LAKE ; DANIO-RERIO ; BIOCHEMICAL-CHARACTERIZATION ; CORYDORAS-PALEATUS ; SEASONAL DYNAMICS ; SUBTROPICAL CHINA
语种: 英语
WOS记录号: WOS:000255063700021
ISSN号: 0730-7268
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/8172
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Coll Fisheries, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China

Recommended Citation:
Lei, Hehua; Xie, Ping; Chen, Jun; Liang, Gaodao; Dai, Ming; Zhang, Xuezhen.Distribution of toxins in various tissues of crucian carp intraperitoneally injected with hepatotoxic microcystins,ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,2008,27(5):1167-1174
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