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学科主题: Environmental Sciences; Multidisciplinary Sciences
题名: Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp
作者: Li, Li1, 2; Xie, Ping1; Guo, Longgen1; Ke, Zhixin1; Zhou, Qiong1; Liu, Yaqin1; Qiu, Tong1
通讯作者: Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China
关键词: phytoplanktivorous bighead carp ; Microcystis blooms ; microcystin ; liver ; kidney ; pathological and biochemical characterizations ; large fish pen
刊名: THESCIENTIFICWORLDJOURNAL
发表日期: 2008
DOI: 10.1100/tsw.2008.32
卷: 8, 期:0, 页:121-137
收录类别: SCI
文章类型: Article
部门归属: [Li, Li; Xie, Ping; Guo, Longgen; Ke, Zhixin; Zhou, Qiong; Liu, Yaqin; Qiu, Tong] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Li, Li] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences ; Multidisciplinary Sciences
研究领域[WOS]: Environmental Sciences & Ecology ; Science & Technology - Other Topics
摘要: Field and experimental studies were conducted to investigate pathological characterizations and biochemical responses in the liver and kidney of the phytoplanktivorous bighead carp after intraperitoneal (i.p.) administration of microcystins (MCs) and exposure to natural cyanobacterial blooms in Meiliang Bay, Lake Taihu. Bighead carp in field and laboratory studies showed a progressive recovery of structure and function in terms of histological, cellular, and biochemical features. In laboratory study, when fish were i.p. injected with extracted MCs at the doses of 200 and 500 mu g MC- LReq/kg body weight, respectively, liver pathology in bighead carp was observed in a time dose-dependent manner within 24 h postinjection and characterized by disruption of liver structure, condensed cytoplasm, and the appearance of massive hepatocytes with karyopyknosis, karyorrhexis, and karyolysis. In comparison with previous studies on other fish, bighead carp in field study endured higher MC doses and longer-term exposure, but displayed less damage in the liver and kidney. Ultrastructural examination in the liver revealed the presence of lysosome proliferation, suggesting that bighead carp might eliminate or lessen cell damage caused by MCs through lysosome activation. Biochemically, sensitive responses in the antioxidant enzymes and higher basal glutathione concentrations might be responsible for their powerful resistance to MCs, suggesting that bighead carp can be used as biomanipulation fish to counteract cyanotoxin contamination.
英文摘要: Field and experimental studies were conducted to investigate pathological characterizations and biochemical responses in the liver and kidney of the phytoplanktivorous bighead carp after intraperitoneal (i.p.) administration of microcystins (MCs) and exposure to natural cyanobacterial blooms in Meiliang Bay, Lake Taihu. Bighead carp in field and laboratory studies showed a progressive recovery of structure and function in terms of histological, cellular, and biochemical features. In laboratory study, when fish were i.p. injected with extracted MCs at the doses of 200 and 500 mu g MC- LReq/kg body weight, respectively, liver pathology in bighead carp was observed in a time dose-dependent manner within 24 h postinjection and characterized by disruption of liver structure, condensed cytoplasm, and the appearance of massive hepatocytes with karyopyknosis, karyorrhexis, and karyolysis. In comparison with previous studies on other fish, bighead carp in field study endured higher MC doses and longer-term exposure, but displayed less damage in the liver and kidney. Ultrastructural examination in the liver revealed the presence of lysosome proliferation, suggesting that bighead carp might eliminate or lessen cell damage caused by MCs through lysosome activation. Biochemically, sensitive responses in the antioxidant enzymes and higher basal glutathione concentrations might be responsible for their powerful resistance to MCs, suggesting that bighead carp can be used as biomanipulation fish to counteract cyanotoxin contamination.
关键词[WOS]: TROUT ONCORHYNCHUS-MYKISS ; GLUTATHIONE S-TRANSFERASES ; CYCLIC PEPTIDE TOXIN ; CARASSIUS-AURATUS L ; FISH DANIO-RERIO ; OXIDATIVE STRESS ; CYPRINUS-CARPIO ; RAINBOW-TROUT ; CYANOBACTERIA EXTRACT ; LIPID-PEROXIDATION
语种: 英语
WOS记录号: WOS:000254985000012
ISSN号: 1537-744X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/8162
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

Recommended Citation:
Li, Li; Xie, Ping; Guo, Longgen; Ke, Zhixin; Zhou, Qiong; Liu, Yaqin; Qiu, Tong.Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp,THESCIENTIFICWORLDJOURNAL,2008,8():121-137
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