中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 中科院水生所知识产出(2009年前)  > 期刊论文
学科主题: Environmental Sciences; Pharmacology & Pharmacy; Toxicology
题名: Gene expression profiles in liver of zebrafish treated with microcystin-LR
作者: Wei, Lili1, 2, 3; Sun, Baojian1, 2; Song, Lirong1, 2; Nie, Pin1, 2
通讯作者: Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
关键词: microcystin-LR ; gene expression ; immunotoxicity ; tumorigenesis ; zebrafish
刊名: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
发表日期: 2008-07-01
DOI: 10.1016/j.etap.2007.12.007
卷: 26, 期:1, 页:6-12
收录类别: SCI
文章类型: Article
部门归属: [Wei, Lili; Sun, Baojian; Song, Lirong; Nie, Pin] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Wei, Lili; Sun, Baojian; Song, Lirong; Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, Lab Fish Dis, Wuhan 430072, Peoples R China; [Wei, Lili] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
摘要: Microcystin-LR (MC-LR) is the most frequently studied cyclic heptatoxin produced by cyanobacteria, which has tremendous negative impacts on fish, while its molecular mechanism behind remained unclear at present. Here, Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish (Danio rerio) after MC-LR exposure. Among the 14,900 transcripts in the microarray, 273 genes were differentially expressed, in which 243 genes were elevated and 30 were decreased. According to GOstat analysis, MC-LR mainly influenced the cell cycle and mitogen-activated protein kinases (MAPK) signaling pathways. In addition, many immune-related genes were also influenced. These data suggest that MC-LR could promote tumorigenesis and cause immunotoxicity in fish. (C) 2008 Elsevier B.V. All rights reserved.
英文摘要: Microcystin-LR (MC-LR) is the most frequently studied cyclic heptatoxin produced by cyanobacteria, which has tremendous negative impacts on fish, while its molecular mechanism behind remained unclear at present. Here, Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish (Danio rerio) after MC-LR exposure. Among the 14,900 transcripts in the microarray, 273 genes were differentially expressed, in which 243 genes were elevated and 30 were decreased. According to GOstat analysis, MC-LR mainly influenced the cell cycle and mitogen-activated protein kinases (MAPK) signaling pathways. In addition, many immune-related genes were also influenced. These data suggest that MC-LR could promote tumorigenesis and cause immunotoxicity in fish. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: PROTEIN PHOSPHATASES ; CYANOBACTERIAL TOXINS ; DNA MICROARRAYS ; CYPRINUS-CARPIO ; INHIBITION ; MICE ; HEPATOTOXICITY ; PROLIFERATION ; HEPATOCYTES ; CHECKPOINT
语种: 英语
WOS记录号: WOS:000255854500002
ISSN号: 1382-6689
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/8136
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Gene expression profiles in liver of zebrafish treated with microcystin-LR.pdf(289KB)----开放获取--View Download

作者单位: 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Lab Fish Dis, Wuhan 430072, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

Recommended Citation:
Wei, Lili; Sun, Baojian; Song, Lirong; Nie, Pin.Gene expression profiles in liver of zebrafish treated with microcystin-LR,ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2008,26(1):6-12
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wei, Lili]'s Articles
[Sun, Baojian]'s Articles
[Song, Lirong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wei, Lili]‘s Articles
[Sun, Baojian]‘s Articles
[Song, Lirong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Gene expression profiles in liver of zebrafish treated with microcystin-LR.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2016  中国科学院水生生物研究所 - Feedback
Powered by CSpace