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Gene expression profiles in liver of zebrafish treated with microcystin-LR
Wei, Lili1,2,3; Sun, Baojian1,2; Song, Lirong1,2; Nie, Pin1,2; Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2008-07-01
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
Volume26Issue:1Pages:6-12
AbstractMicrocystin-LR (MC-LR) is the most frequently studied cyclic heptatoxin produced by cyanobacteria, which has tremendous negative impacts on fish, while its molecular mechanism behind remained unclear at present. Here, Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish (Danio rerio) after MC-LR exposure. Among the 14,900 transcripts in the microarray, 273 genes were differentially expressed, in which 243 genes were elevated and 30 were decreased. According to GOstat analysis, MC-LR mainly influenced the cell cycle and mitogen-activated protein kinases (MAPK) signaling pathways. In addition, many immune-related genes were also influenced. These data suggest that MC-LR could promote tumorigenesis and cause immunotoxicity in fish. (C) 2008 Elsevier B.V. All rights reserved.; Microcystin-LR (MC-LR) is the most frequently studied cyclic heptatoxin produced by cyanobacteria, which has tremendous negative impacts on fish, while its molecular mechanism behind remained unclear at present. Here, Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish (Danio rerio) after MC-LR exposure. Among the 14,900 transcripts in the microarray, 273 genes were differentially expressed, in which 243 genes were elevated and 30 were decreased. According to GOstat analysis, MC-LR mainly influenced the cell cycle and mitogen-activated protein kinases (MAPK) signaling pathways. In addition, many immune-related genes were also influenced. These data suggest that MC-LR could promote tumorigenesis and cause immunotoxicity in fish. (C) 2008 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordMicrocystin-lr Gene Expression Immunotoxicity Tumorigenesis Zebrafish
Department[Wei, Lili; Sun, Baojian; Song, Lirong; Nie, Pin] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Wei, Lili; Sun, Baojian; Song, Lirong; Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, Lab Fish Dis, Wuhan 430072, Peoples R China; [Wei, Lili] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
Subject AreaEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
DOI10.1016/j.etap.2007.12.007
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000255854500002
WOS KeywordPROTEIN PHOSPHATASES ; CYANOBACTERIAL TOXINS ; DNA MICROARRAYS ; CYPRINUS-CARPIO ; INHIBITION ; MICE ; HEPATOTOXICITY ; PROLIFERATION ; HEPATOCYTES ; CHECKPOINT
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Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/8136
Collection期刊论文
Corresponding AuthorNie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Lab Fish Dis, Wuhan 430072, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
Recommended Citation
GB/T 7714
Wei, Lili,Sun, Baojian,Song, Lirong,et al. Gene expression profiles in liver of zebrafish treated with microcystin-LR[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2008,26(1):6-12.
APA Wei, Lili,Sun, Baojian,Song, Lirong,Nie, Pin,&Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2008).Gene expression profiles in liver of zebrafish treated with microcystin-LR.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,26(1),6-12.
MLA Wei, Lili,et al."Gene expression profiles in liver of zebrafish treated with microcystin-LR".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 26.1(2008):6-12.
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