| Gene expression profiles in liver of zebrafish treated with microcystin-LR | |
| Wei, Lili1,2,3; Sun, Baojian1,2; Song, Lirong1,2; Nie, Pin1,2; Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China | |
| 2008-07-01 | |
| Source Publication | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| ISSN | 1382-6689 |
| Volume | 26Issue:1Pages:6-12 |
| Abstract | Microcystin-LR (MC-LR) is the most frequently studied cyclic heptatoxin produced by cyanobacteria, which has tremendous negative impacts on fish, while its molecular mechanism behind remained unclear at present. Here, Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish (Danio rerio) after MC-LR exposure. Among the 14,900 transcripts in the microarray, 273 genes were differentially expressed, in which 243 genes were elevated and 30 were decreased. According to GOstat analysis, MC-LR mainly influenced the cell cycle and mitogen-activated protein kinases (MAPK) signaling pathways. In addition, many immune-related genes were also influenced. These data suggest that MC-LR could promote tumorigenesis and cause immunotoxicity in fish. (C) 2008 Elsevier B.V. All rights reserved.; Microcystin-LR (MC-LR) is the most frequently studied cyclic heptatoxin produced by cyanobacteria, which has tremendous negative impacts on fish, while its molecular mechanism behind remained unclear at present. Here, Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish (Danio rerio) after MC-LR exposure. Among the 14,900 transcripts in the microarray, 273 genes were differentially expressed, in which 243 genes were elevated and 30 were decreased. According to GOstat analysis, MC-LR mainly influenced the cell cycle and mitogen-activated protein kinases (MAPK) signaling pathways. In addition, many immune-related genes were also influenced. These data suggest that MC-LR could promote tumorigenesis and cause immunotoxicity in fish. (C) 2008 Elsevier B.V. All rights reserved. |
| Subtype | Article |
| Keyword | Microcystin-lr Gene Expression Immunotoxicity Tumorigenesis Zebrafish |
| Department | [Wei, Lili; Sun, Baojian; Song, Lirong; Nie, Pin] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Wei, Lili; Sun, Baojian; Song, Lirong; Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, Lab Fish Dis, Wuhan 430072, Peoples R China; [Wei, Lili] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China |
| Subject Area | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| DOI | 10.1016/j.etap.2007.12.007 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| WOS Subject | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| WOS ID | WOS:000255854500002 |
| WOS Keyword | PROTEIN PHOSPHATASES ; CYANOBACTERIAL TOXINS ; DNA MICROARRAYS ; CYPRINUS-CARPIO ; INHIBITION ; MICE ; HEPATOTOXICITY ; PROLIFERATION ; HEPATOCYTES ; CHECKPOINT |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/152342/8136 |
| Collection | 期刊论文 |
| Corresponding Author | Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Lab Fish Dis, Wuhan 430072, Peoples R China 3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China |
| Recommended Citation GB/T 7714 | Wei, Lili,Sun, Baojian,Song, Lirong,et al. Gene expression profiles in liver of zebrafish treated with microcystin-LR[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2008,26(1):6-12. |
| APA | Wei, Lili,Sun, Baojian,Song, Lirong,Nie, Pin,&Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2008).Gene expression profiles in liver of zebrafish treated with microcystin-LR.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,26(1),6-12. |
| MLA | Wei, Lili,et al."Gene expression profiles in liver of zebrafish treated with microcystin-LR".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 26.1(2008):6-12. |
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