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Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls
Wen, Sheng1,2; Yang, Fang-Xing1; Gong, Yan1,2; Zhang, Xiao-Ling1,2; Hui, Yang1; Li, Jing-Guang3; Liu, Ai-Ling4,5; Wu, Yong-Ning3; Lu, Wen-Qing4,5; Xu, Ying1; Xu, Y, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
2008-06-01
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume42Issue:11Pages:4202-4207
AbstractTo investigate the occupational exposure levels to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs), indoor dust (n = 3) in workshops and hair samples from male workers (n = 64) were collected at two electrical and electronic equipment waste (E-waste) dismantling factories located in the LQ area in east China in July 11-13, 2006. Pre- and postworkshift urines (64 of each) were also collected from the workers to study oxidative damage to DNA using 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker. The concentrations of PCDD/Fs, PCDD/F-WHO-TEQs, PBDEs, PCBs and PCB-WHO-TEQs were (50.0 +/- 8.1) x 10(3), 724.1 +/- 249.6, (27.5 +/- 5.8) x 10(6), (1.6 +/- 0.4) x 10(9), (26.2 +/- 3.0) x 10(3) pg/g dry weight (dw) in dust, and (2.6 +/- 0.6) x 10(3), 42.4 +/- 9.3, (870.8 +/- 205.4) x 10(3), (1.6 +/- 0.2) x 10(6), 41.5 +/- 5.5 pg/g dw in hair, respectively. The homologue and congener profiles in the samples demonstrated that high concentrations of PCDD/Fs, PBDEs, and PCBs were originated from open burning of E-waste. The 8-OHdG levels were detected at 6.40 +/- 1.64 mu mol/mol creatinine in preworkshift urines. However, the levels significantly increased to 24.55 +/- 5.96 mu mol/mol creatinine in postworkshift urines (p < 0.05). Then, it is concluded that there is a high cancer risk originated from oxidative stress indicated by the elevated 8-OHdG levels in the E-waste dismantling workers exposed to high concentrations of PCDD/Fs, PBDEs, and PCBs.; To investigate the occupational exposure levels to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs), indoor dust (n = 3) in workshops and hair samples from male workers (n = 64) were collected at two electrical and electronic equipment waste (E-waste) dismantling factories located in the LQ area in east China in July 11-13, 2006. Pre- and postworkshift urines (64 of each) were also collected from the workers to study oxidative damage to DNA using 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker. The concentrations of PCDD/Fs, PCDD/F-WHO-TEQs, PBDEs, PCBs and PCB-WHO-TEQs were (50.0 +/- 8.1) x 10(3), 724.1 +/- 249.6, (27.5 +/- 5.8) x 10(6), (1.6 +/- 0.4) x 10(9), (26.2 +/- 3.0) x 10(3) pg/g dry weight (dw) in dust, and (2.6 +/- 0.6) x 10(3), 42.4 +/- 9.3, (870.8 +/- 205.4) x 10(3), (1.6 +/- 0.2) x 10(6), 41.5 +/- 5.5 pg/g dw in hair, respectively. The homologue and congener profiles in the samples demonstrated that high concentrations of PCDD/Fs, PBDEs, and PCBs were originated from open burning of E-waste. The 8-OHdG levels were detected at 6.40 +/- 1.64 mu mol/mol creatinine in preworkshift urines. However, the levels significantly increased to 24.55 +/- 5.96 mu mol/mol creatinine in postworkshift urines (p < 0.05). Then, it is concluded that there is a high cancer risk originated from oxidative stress indicated by the elevated 8-OHdG levels in the E-waste dismantling workers exposed to high concentrations of PCDD/Fs, PBDEs, and PCBs.
SubtypeArticle
KeywordOxidative Dna-damage
Department[Wen, Sheng; Yang, Fang-Xing; Gong, Yan; Zhang, Xiao-Ling; Hui, Yang; Xu, Ying] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Wen, Sheng; Gong, Yan; Zhang, Xiao-Ling] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; [Li, Jing-Guang; Wu, Yong-Ning] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Food Safety, Beijing 100050, Peoples R China; [Liu, Ai-Ling; Lu, Wen-Qing] Huazhong Univ Sci & Technol, Dept Environm & Occupat Hlth, Sch Publ Hlth, Tongji Med Coll, Wuhan 430030, Peoples R China; [Liu, Ai-Ling; Lu, Wen-Qing] Huazhong Univ Sci & Technol, Minist Educ, Sch Publ Hlth, Tongji Med Coll,Key Lab Environm & Hlth, Wuhan 430030, Peoples R China
Subject AreaEngineering ; Environmental ; Environmental Sciences
DOI10.1021/es800044m
WOS HeadingsScience & Technology ; Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000256274300050
WOS KeywordOXIDATIVE DNA-DAMAGE ; PERSISTENT ORGANIC POLLUTANTS ; WASTE RECYCLING SITE ; IN-HOUSE DUST ; SOUTHEAST CHINA ; PCBS ; 8-HYDROXY-2'-DEOXYGUANOSINE ; 8-HYDROXYDEOXYGUANOSINE ; STRESS ; POLLUTION
Citation statistics
Cited Times:81[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/8110
Collection期刊论文
Corresponding AuthorXu, Y, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Food Safety, Beijing 100050, Peoples R China
4.Huazhong Univ Sci & Technol, Dept Environm & Occupat Hlth, Sch Publ Hlth, Tongji Med Coll, Wuhan 430030, Peoples R China
5.Huazhong Univ Sci & Technol, Minist Educ, Sch Publ Hlth, Tongji Med Coll,Key Lab Environm & Hlth, Wuhan 430030, Peoples R China
Recommended Citation
GB/T 7714
Wen, Sheng,Yang, Fang-Xing,Gong, Yan,et al. Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2008,42(11):4202-4207.
APA Wen, Sheng.,Yang, Fang-Xing.,Gong, Yan.,Zhang, Xiao-Ling.,Hui, Yang.,...&Xu, Y, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China.(2008).Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls.ENVIRONMENTAL SCIENCE & TECHNOLOGY,42(11),4202-4207.
MLA Wen, Sheng,et al."Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls".ENVIRONMENTAL SCIENCE & TECHNOLOGY 42.11(2008):4202-4207.
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