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学科主题: Fisheries; Marine & Freshwater Biology
题名: Ultrastructural alteration of lymphocytes in spleen and pronephros of grass carp (Ctenopharyngodon idella) experimentally exposed to microcystin-LR
作者: Wei, Li Li1, 2, 3; Sun, Bao Jian1, 2; Nie, Pin1, 2
通讯作者: Nie, P, Chinese Acad Sci, State Key Lab Freshwater & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
关键词: microcystin-LR ; apoptosis ; mitochondrion ; edema ; immunotoxicity ; grass carp ; spleen ; pronephros
刊名: AQUACULTURE
发表日期: 2008-08-01
DOI: 10.1016/j.aquaculture.2008.05.015
卷: 280, 期:1-4, 页:270-275
收录类别: SCI
文章类型: Article
部门归属: [Wei, Li Li; Sun, Bao Jian; Nie, Pin] Chinese Acad Sci, State Key Lab Freshwater & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Wei, Li Li; Sun, Bao Jian; Nie, Pin] Chinese Acad Sci, Lab Fish Dis, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Wei, Li Li] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [20577065]
类目[WOS]: Fisheries ; Marine & Freshwater Biology
研究领域[WOS]: Fisheries ; Marine & Freshwater Biology
摘要: Relatively little is known in relation to pathological changes of immune organs in fish when exposed to MC-LR. The ultrastructural alteration of lymphocytes was examined in the spleen and pronephros of grass carp Ctenopharyngodon idella injected experimentally with microcystin-LR. The fish were intraperitoneally injected with MC-LR at a dose of 50 mu g/kg body weight, and the spleen and pronephros were dissected out at 1, 2, 7, 14 and 21 days post intraperitoneal injection (dpi). Pathological changes were then examined by transmission electron microscopy. Apoptosis was detected only in lymphocytes in the spleen, with obvious apoptotic features observed at 2 dpi; pathological changes of lymphocytes in the pronephros were also serious with mitochondria being highly edematous. However, damaged lymphocytes were almost un-observed in the spleen and pronephros at 21 dpi. These findings suggest that MC-LR can induce toxic effect on immune organs in grass carp, and the spleen may be much more sensitive to MC-LR stimulation. (C) 2008 Elsevier B.V. All rights reserved.
英文摘要: Relatively little is known in relation to pathological changes of immune organs in fish when exposed to MC-LR. The ultrastructural alteration of lymphocytes was examined in the spleen and pronephros of grass carp Ctenopharyngodon idella injected experimentally with microcystin-LR. The fish were intraperitoneally injected with MC-LR at a dose of 50 mu g/kg body weight, and the spleen and pronephros were dissected out at 1, 2, 7, 14 and 21 days post intraperitoneal injection (dpi). Pathological changes were then examined by transmission electron microscopy. Apoptosis was detected only in lymphocytes in the spleen, with obvious apoptotic features observed at 2 dpi; pathological changes of lymphocytes in the pronephros were also serious with mitochondria being highly edematous. However, damaged lymphocytes were almost un-observed in the spleen and pronephros at 21 dpi. These findings suggest that MC-LR can induce toxic effect on immune organs in grass carp, and the spleen may be much more sensitive to MC-LR stimulation. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: RAT HEPATOCYTES ; CYCLOSPORINE-A ; APOPTOSIS ; TROUT ; HEPATOTOXICITY ; ACCUMULATION ; PATHOLOGY ; TOXINS ; DEATH
语种: 英语
WOS记录号: WOS:000258965200041
ISSN号: 0044-8486
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/8024
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Freshwater & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Lab Fish Dis, Inst Hydrobiol, Wuhan 430072, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

Recommended Citation:
Wei, Li Li; Sun, Bao Jian; Nie, Pin.Ultrastructural alteration of lymphocytes in spleen and pronephros of grass carp (Ctenopharyngodon idella) experimentally exposed to microcystin-LR,AQUACULTURE,2008,280(1-4):270-275
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