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Molecular characterization and expression pattern of fetuin-B in gibel carp (Carassius auratus gibelio)
Liu, Jing-Xia; Zhai, Yan-Hua; Geng, Fan-Suo; Xia, Jian-Hong; Gui, Jian-Fang; Gui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2008-10-01
Source PublicationBIOCHEMICAL GENETICS
ISSN0006-2928
Volume46Issue:9-10Pages:620-633
AbstractFetuin-B has recently been cloned and identified from rats, mice, and humans; their expression patterns, however, have not been elucidated yet. In this study, Cagfetuin-B has been cloned in gibel carp. RT-PCR and Western blot detection revealed that Cagfetuin-B is first transcribed from the blastula stage and at a relatively stable level afterward during embryogenesis and the larval stage. Cagfetuin-B transcripts are predominantly distributed over the yolk syncytial layer in the early embryos and later restricted to the cells of liver and brain in newly hatched larvae. Moreover, a dynamic distribution of Cagfetuin-B protein was observed in brain, kidney, liver, and skin during morphogenesis. In adult fish, Cagfetuin-B transcripts are restricted in liver and ovary. Our work, for the first time, revealed the extra-hepatic transcription and a dynamic distribution of fetuin-B during embryogenesis and in adults, which indicates the potential roles of fetuin-B in fish organogenesis.; Fetuin-B has recently been cloned and identified from rats, mice, and humans; their expression patterns, however, have not been elucidated yet. In this study, Cagfetuin-B has been cloned in gibel carp. RT-PCR and Western blot detection revealed that Cagfetuin-B is first transcribed from the blastula stage and at a relatively stable level afterward during embryogenesis and the larval stage. Cagfetuin-B transcripts are predominantly distributed over the yolk syncytial layer in the early embryos and later restricted to the cells of liver and brain in newly hatched larvae. Moreover, a dynamic distribution of Cagfetuin-B protein was observed in brain, kidney, liver, and skin during morphogenesis. In adult fish, Cagfetuin-B transcripts are restricted in liver and ovary. Our work, for the first time, revealed the extra-hepatic transcription and a dynamic distribution of fetuin-B during embryogenesis and in adults, which indicates the potential roles of fetuin-B in fish organogenesis.
SubtypeArticle
KeywordFetuin-b Embryogenesis Organogenesis Extra-hepatic Transcription Gibel Carp
Department[Liu, Jing-Xia; Zhai, Yan-Hua; Geng, Fan-Suo; Xia, Jian-Hong; Gui, Jian-Fang] Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Subject AreaBiochemistry & Molecular Biology ; Genetics & Heredity
DOI10.1007/s10528-008-9176-4
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Major Basic Research Program [2004CB117401] ; National Major Basic Research Program [2004CB117401] ; National Major Basic Research Program [2004CB117401] ; National Major Basic Research Program [2004CB117401]
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Genetics & Heredity
WOS SubjectBiochemistry & Molecular Biology ; Genetics & Heredity
WOS IDWOS:000259063800009
WOS KeywordSILVER CRUCIAN CARP ; RAT FETUIN ; GLYCOPROTEIN/FETUIN-A ; INSULIN-RECEPTOR ; TYROSINE KINASE ; PROTEIN ; GENE ; INHIBITOR ; FAMILY ; MEMBER
Funding OrganizationNational Major Basic Research Program [2004CB117401] ; National Major Basic Research Program [2004CB117401] ; National Major Basic Research Program [2004CB117401] ; National Major Basic Research Program [2004CB117401]
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/8016
Collection期刊论文
Corresponding AuthorGui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
AffiliationChinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jing-Xia,Zhai, Yan-Hua,Geng, Fan-Suo,et al. Molecular characterization and expression pattern of fetuin-B in gibel carp (Carassius auratus gibelio)[J]. BIOCHEMICAL GENETICS,2008,46(9-10):620-633.
APA Liu, Jing-Xia,Zhai, Yan-Hua,Geng, Fan-Suo,Xia, Jian-Hong,Gui, Jian-Fang,&Gui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2008).Molecular characterization and expression pattern of fetuin-B in gibel carp (Carassius auratus gibelio).BIOCHEMICAL GENETICS,46(9-10),620-633.
MLA Liu, Jing-Xia,et al."Molecular characterization and expression pattern of fetuin-B in gibel carp (Carassius auratus gibelio)".BIOCHEMICAL GENETICS 46.9-10(2008):620-633.
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