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学科主题: Biochemistry & Molecular Biology; Genetics & Heredity
题名: Molecular characterization and expression pattern of fetuin-B in gibel carp (Carassius auratus gibelio)
作者: Liu, Jing-Xia1; Zhai, Yan-Hua1; Geng, Fan-Suo1; Xia, Jian-Hong1; Gui, Jian-Fang1
通讯作者: Gui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
关键词: fetuin-B ; embryogenesis ; organogenesis ; extra-hepatic transcription ; gibel carp
刊名: BIOCHEMICAL GENETICS
发表日期: 2008-10-01
DOI: 10.1007/s10528-008-9176-4
卷: 46, 期:9-10, 页:620-633
收录类别: SCI
文章类型: Article
部门归属: [Liu, Jing-Xia; Zhai, Yan-Hua; Geng, Fan-Suo; Xia, Jian-Hong; Gui, Jian-Fang] Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Major Basic Research Program [2004CB117401]
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
摘要: Fetuin-B has recently been cloned and identified from rats, mice, and humans; their expression patterns, however, have not been elucidated yet. In this study, Cagfetuin-B has been cloned in gibel carp. RT-PCR and Western blot detection revealed that Cagfetuin-B is first transcribed from the blastula stage and at a relatively stable level afterward during embryogenesis and the larval stage. Cagfetuin-B transcripts are predominantly distributed over the yolk syncytial layer in the early embryos and later restricted to the cells of liver and brain in newly hatched larvae. Moreover, a dynamic distribution of Cagfetuin-B protein was observed in brain, kidney, liver, and skin during morphogenesis. In adult fish, Cagfetuin-B transcripts are restricted in liver and ovary. Our work, for the first time, revealed the extra-hepatic transcription and a dynamic distribution of fetuin-B during embryogenesis and in adults, which indicates the potential roles of fetuin-B in fish organogenesis.
英文摘要: Fetuin-B has recently been cloned and identified from rats, mice, and humans; their expression patterns, however, have not been elucidated yet. In this study, Cagfetuin-B has been cloned in gibel carp. RT-PCR and Western blot detection revealed that Cagfetuin-B is first transcribed from the blastula stage and at a relatively stable level afterward during embryogenesis and the larval stage. Cagfetuin-B transcripts are predominantly distributed over the yolk syncytial layer in the early embryos and later restricted to the cells of liver and brain in newly hatched larvae. Moreover, a dynamic distribution of Cagfetuin-B protein was observed in brain, kidney, liver, and skin during morphogenesis. In adult fish, Cagfetuin-B transcripts are restricted in liver and ovary. Our work, for the first time, revealed the extra-hepatic transcription and a dynamic distribution of fetuin-B during embryogenesis and in adults, which indicates the potential roles of fetuin-B in fish organogenesis.
关键词[WOS]: SILVER CRUCIAN CARP ; RAT FETUIN ; GLYCOPROTEIN/FETUIN-A ; INSULIN-RECEPTOR ; TYROSINE KINASE ; PROTEIN ; GENE ; INHIBITOR ; FAMILY ; MEMBER
语种: 英语
WOS记录号: WOS:000259063800009
ISSN号: 0006-2928
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/8016
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

Recommended Citation:
Liu, Jing-Xia; Zhai, Yan-Hua; Geng, Fan-Suo; Xia, Jian-Hong; Gui, Jian-Fang.Molecular characterization and expression pattern of fetuin-B in gibel carp (Carassius auratus gibelio),BIOCHEMICAL GENETICS,2008,46(9-10):620-633
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