| In vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and ion regulation in liver and heart of rabbit | |
| Zhao, Yanyan2; Xie, Ping1,2; Tang, Rong1,2; Zhang, Xuezhen2; Li, Li2; Li, Dapeng1,2; Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China | |
| 2008-09-01 | |
| Source Publication | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
 |
| ISSN | 1532-0456 |
| Volume | 148Issue:3Pages:204-210 |
| Abstract | This study examined the toxic effects of microcystins on mitochondria of liver and heart of rabbit in vivo. Rabbits were injected i.p. with extracted microcystins (mainly MC-RR and -LR) at two doses, 12.5 and 50 MCLReq. mu g/kg bw, and the changes in mitochondria of liver and heart were studied at 1, 3,12, 24 and 48 h after injection. MCs induced damage of mitochondrial morphology and lipid peroxidation in both liver and heart. MCs influenced respiratory activity through inhibiting NADH dehydrogenase and enhancing succinate dehydrogenase (SDH). MCs altered Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities of mitochondria and consequently disrupted ionic homeostasis, which might be partly responsible for the loss of mitochondrial membrane potential (MMP). MCs were highly toxic to mitochondria with more serious damage in liver than in heart. Damage of mitochondria showed reduction at 48 h in the low dose group, suggesting that the low dose of MCs might have stimulated a compensatory response in the rabbits. (C) 2008 Elsevier Inc. All rights reserved.; This study examined the toxic effects of microcystins on mitochondria of liver and heart of rabbit in vivo. Rabbits were injected i.p. with extracted microcystins (mainly MC-RR and -LR) at two doses, 12.5 and 50 MCLReq. mu g/kg bw, and the changes in mitochondria of liver and heart were studied at 1, 3,12, 24 and 48 h after injection. MCs induced damage of mitochondrial morphology and lipid peroxidation in both liver and heart. MCs influenced respiratory activity through inhibiting NADH dehydrogenase and enhancing succinate dehydrogenase (SDH). MCs altered Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities of mitochondria and consequently disrupted ionic homeostasis, which might be partly responsible for the loss of mitochondrial membrane potential (MMP). MCs were highly toxic to mitochondria with more serious damage in liver than in heart. Damage of mitochondria showed reduction at 48 h in the low dose group, suggesting that the low dose of MCs might have stimulated a compensatory response in the rabbits. (C) 2008 Elsevier Inc. All rights reserved. |
| Subtype | Article |
| Keyword | Ion regulatIon Microcystins Mitochondria Oxidative Stress Respiratory Chain Enzymes Ultrastructural Changes |
| Department | [Xie, Ping; Tang, Rong; Li, Dapeng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; [Zhao, Yanyan; Xie, Ping; Tang, Rong; Zhang, Xuezhen; Li, Li; Li, Dapeng] Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430072, Peoples R China |
| Subject Area | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology |
| DOI | 10.1016/j.cbpc.2008.05.008 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Funding Organization | Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology |
| WOS Subject | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology |
| WOS ID | WOS:000259350900002 |
| WOS Keyword | PHYTOPLANKTIVOROUS SILVER CARP ; OXIDATIVE STRESS RESPONSES ; ULTRASTRUCTURAL-CHANGES ; LABORATORY CONDITIONS ; PROTEIN PHOSPHATASES ; INDUCED APOPTOSIS ; ESTUARINE CRAB ; LR ; KIDNEY ; MICE |
| Funding Organization | Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/152342/8008 |
| Collection | 期刊论文 |
| Corresponding Author | Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China 2.Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430072, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Yanyan,Xie, Ping,Tang, Rong,et al. In vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and ion regulation in liver and heart of rabbit[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2008,148(3):204-210. |
| APA | Zhao, Yanyan.,Xie, Ping.,Tang, Rong.,Zhang, Xuezhen.,Li, Li.,...&Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China.(2008).In vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and ion regulation in liver and heart of rabbit.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,148(3),204-210. |
| MLA | Zhao, Yanyan,et al."In vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and ion regulation in liver and heart of rabbit".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 148.3(2008):204-210. |
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