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Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection
Wang, Qjng; Xie, Ping; Chen, Jun; Liang, Gaodao; Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China
2008-11-01
Source PublicationTOXICON
ISSN0041-0101
Volume52Issue:6Pages:721-727
AbstractThe distribution of microcystins (MCs) in various tissues of Wistar rats was studied under laboratory conditions. Rats were injected intravenously (i.v.) with extracted MCs at a dose of 80 mu g MC-LRequivalent/kg body weight. MCs concentrations in various tissues were detected at 1, 2. 4, 6, 12 and 24 h post-injection using liquid chromatography-mass spectrometry (LC-MS). The highest concentration of MCs was found in kidney (0.034-0.295 mu g/g dry weight), followed by lung (0.007-0.067 mu g/g dry weight), stomach (0.010-0.058 mu g/g dry weight) and liver (0.003-0.052 mu g/g dry weight). The maximum MCs content in the whole body of rat, 2.9% of the injected dose, was observed at 2 h post-injection. MCs concentration was higher in kidney than in liver during the experiment, and two peaks of MCs concentration (at 2 and 24 h, respectively) were observed in kidney, indicating that MCs can be excreted directly via kidney of rat. Though heart, intestine, spleen, brain, gonad and stomach contained less than 0.2% of injected MCs during the whole experiment stage, the presence of MCs in these tissues represents potential damage to them. (c) 2008 Elsevier Ltd. All Fights reserved.; The distribution of microcystins (MCs) in various tissues of Wistar rats was studied under laboratory conditions. Rats were injected intravenously (i.v.) with extracted MCs at a dose of 80 mu g MC-LRequivalent/kg body weight. MCs concentrations in various tissues were detected at 1, 2. 4, 6, 12 and 24 h post-injection using liquid chromatography-mass spectrometry (LC-MS). The highest concentration of MCs was found in kidney (0.034-0.295 mu g/g dry weight), followed by lung (0.007-0.067 mu g/g dry weight), stomach (0.010-0.058 mu g/g dry weight) and liver (0.003-0.052 mu g/g dry weight). The maximum MCs content in the whole body of rat, 2.9% of the injected dose, was observed at 2 h post-injection. MCs concentration was higher in kidney than in liver during the experiment, and two peaks of MCs concentration (at 2 and 24 h, respectively) were observed in kidney, indicating that MCs can be excreted directly via kidney of rat. Though heart, intestine, spleen, brain, gonad and stomach contained less than 0.2% of injected MCs during the whole experiment stage, the presence of MCs in these tissues represents potential damage to them. (c) 2008 Elsevier Ltd. All Fights reserved.
SubtypeArticle
KeywordMicrocystins Intravenous Injection Wistar Rat Tissue Distribution
Department[Wang, Qjng; Xie, Ping; Chen, Jun; Liang, Gaodao] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
Subject AreaPharmacology & Pharmacy ; Toxicology
DOI10.1016/j.toxicon.2008.08.004
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30700077] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30700077] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30700077] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30700077]
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS IDWOS:000261013300008
WOS KeywordFRESH-WATER SNAIL ; BIOCHEMICAL-CHARACTERIZATION ; HEPATOTOXIC MICROCYSTINS ; TISSUE DISTRIBUTIONS ; PROTEIN PHOSPHATASE ; SEASONAL DYNAMICS ; SUBTROPICAL CHINA ; EUTROPHIC LAKE ; CELL-EXTRACTS ; LARGE SHALLOW
Funding OrganizationNational Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30700077] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30700077] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30700077] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30700077]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/7960
Collection期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China
AffiliationChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qjng,Xie, Ping,Chen, Jun,et al. Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection[J]. TOXICON,2008,52(6):721-727.
APA Wang, Qjng,Xie, Ping,Chen, Jun,Liang, Gaodao,&Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China.(2008).Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection.TOXICON,52(6),721-727.
MLA Wang, Qjng,et al."Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection".TOXICON 52.6(2008):721-727.
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