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Changes in plasma thyroid hormones and cortisol levels in crucian carp (Carassius auratus) exposed to the extracted microcystins
Li, Dapeng1,2; Xie, Ping1,2; Zhang, Xuezhen2; Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu S Rd 7, Wuhan 430072, Peoples R China
2008-12-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume74Issue:1Pages:13-18
AbstractThe endocrine response of crucian carp injected intraperitoneally with extracted microcystins (MC) was investigated in this study. Fish were injected intraperitoneally either with 0.75% NaCl (control) and Microcystis extract corresponding to 150 and 600 mu g microcystins per kg body weight. The plasma levels of triiodothyronine (T-3), thyroxine (T-4), free triiodothyronine (FT3), free thyroxine (FT4), and cortisol were determined at 0, 1, 3, 12, 24. and 48 h post-administration of MC-containing extract. Treated fish displayed abnormal behaviors, Such as a startle response and disoriented swimming, as well as changes in ventilation rates. Plasma cortisol concentrations of fish in both dose groups significantly increased after administration of extracted MC and remained high throughout the experiment, which suggested that MC elicited a stress response in treated fish. The profiles of cortisol changes in treated fish appeared to be dose dependent, indicating that fish in the high dose group experienced greater MC-incluced disturbance. Mortality occurred after 12 h in the high dose group. Plasma levels of T-4, T-3, FT4, and FT3 did not vary significantly between the control fish. In contrast to this, fish exposed to MC-containing extract showed significant declines in T-3, FT4, and FT3 levels in a dose-depenclent manner throughout the experiment. Plasma T4 levels, however, did not vary significantly in the low dose group, whereas they decreased significantly it 48 h post injection in the high dose group. This study demonstrates that administration of microcystins-containing extract causes a stress response and reduces the plasma levels of thyroid hormones in crucian carp. These results illustrate that microcystins exerted potent effects on the endocrine system of crucian carp, through activating their hypothalamus-pituitary- interrenal axis and disturbing thyroid function. (c) 2008 Elsevier Ltd. All rights reserved.; The endocrine response of crucian carp injected intraperitoneally with extracted microcystins (MC) was investigated in this study. Fish were injected intraperitoneally either with 0.75% NaCl (control) and Microcystis extract corresponding to 150 and 600 mu g microcystins per kg body weight. The plasma levels of triiodothyronine (T(3)), thyroxine (T(4)), free triiodothyronine (FT(3)), free thyroxine (FT(4)), and cortisol were determined at 0, 1, 3, 12, 24. and 48 h post-administration of MC-containing extract. Treated fish displayed abnormal behaviors, Such as a startle response and disoriented swimming, as well as changes in ventilation rates. Plasma cortisol concentrations of fish in both dose groups significantly increased after administration of extracted MC and remained high throughout the experiment, which suggested that MC elicited a stress response in treated fish. The profiles of cortisol changes in treated fish appeared to be dose dependent, indicating that fish in the high dose group experienced greater MC-incluced disturbance. Mortality occurred after 12 h in the high dose group. Plasma levels of T(4), T(3), FT(4), and FT(3) did not vary significantly between the control fish. In contrast to this, fish exposed to MC-containing extract showed significant declines in T(3), FT(4), and FT(3) levels in a dose-depenclent manner throughout the experiment. Plasma T4 levels, however, did not vary significantly in the low dose group, whereas they decreased significantly it 48 h post injection in the high dose group. This study demonstrates that administration of microcystins-containing extract causes a stress response and reduces the plasma levels of thyroid hormones in crucian carp. These results illustrate that microcystins exerted potent effects on the endocrine system of crucian carp, through activating their hypothalamus-pituitary- interrenal axis and disturbing thyroid function. (c) 2008 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordMicrocystin Thyroxine Stress Endocrine Fish
Department[Li, Dapeng; Xie, Ping] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Li, Dapeng; Xie, Ping; Zhang, Xuezhen] Huazhong Agr Univ, Coll Fisheries, Minist Agr, Key Lab Freshwater Biodivers Conservat & Utilizat, Wuhan 430070, Peoples R China
Subject AreaEnvironmental Sciences
DOI10.1016/j.chemosphere.2008.09.065
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationFluazhong Agricultural University ; National Basic Research Program of China (973 Program) [2008CB418101] ; Fluazhong Agricultural University ; National Basic Research Program of China (973 Program) [2008CB418101] ; Fluazhong Agricultural University ; National Basic Research Program of China (973 Program) [2008CB418101] ; Fluazhong Agricultural University ; National Basic Research Program of China (973 Program) [2008CB418101]
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000263140000003
WOS KeywordTILAPIA OREOCHROMIS-NILOTICUS ; CYPRINUS-CARPIO ; BROWN TROUT ; IODOTHYRONINE DEIODINASE ; RAINBOW-TROUT ; ORAL TOXICITY ; SALMO-TRUTTA ; FISH ; STRESS ; GROWTH
Funding OrganizationFluazhong Agricultural University ; National Basic Research Program of China (973 Program) [2008CB418101] ; Fluazhong Agricultural University ; National Basic Research Program of China (973 Program) [2008CB418101] ; Fluazhong Agricultural University ; National Basic Research Program of China (973 Program) [2008CB418101] ; Fluazhong Agricultural University ; National Basic Research Program of China (973 Program) [2008CB418101]
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/7890
Collection期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu S Rd 7, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Coll Fisheries, Minist Agr, Key Lab Freshwater Biodivers Conservat & Utilizat, Wuhan 430070, Peoples R China
Recommended Citation
GB/T 7714
Li, Dapeng,Xie, Ping,Zhang, Xuezhen,et al. Changes in plasma thyroid hormones and cortisol levels in crucian carp (Carassius auratus) exposed to the extracted microcystins[J]. CHEMOSPHERE,2008,74(1):13-18.
APA Li, Dapeng,Xie, Ping,Zhang, Xuezhen,&Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu S Rd 7, Wuhan 430072, Peoples R China.(2008).Changes in plasma thyroid hormones and cortisol levels in crucian carp (Carassius auratus) exposed to the extracted microcystins.CHEMOSPHERE,74(1),13-18.
MLA Li, Dapeng,et al."Changes in plasma thyroid hormones and cortisol levels in crucian carp (Carassius auratus) exposed to the extracted microcystins".CHEMOSPHERE 74.1(2008):13-18.
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