| Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins | |
| Zhao, Yanyan2; Xie, Ping1,2; Zhang, Xuezhen2; Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China | |
| 2009-03-01 | |
| Source Publication | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| ISSN | 1382-6689 |
| Volume | 27Issue:2Pages:195-199 |
| Abstract | Oxidative stress response after prolonged exposure to a low dose of microcystins (MCs) was studied in liver, kidney and brain of domestic rabbits. Rabbits were treated with extracted MCs (mainly MC-LR and MC-RR) at a dose of 2 MC-LReq. mu g/kg body weight or saline solution every 24 h for 7 or 14 days. During the exposure of MCs, increase of lipid peroxidation (LPO) levels were detected in all the organs studied, while antioxidant enzymes responded differently among different organs. The enzyme activities Of Superoxide dismutase (SOD). catalase (CAT) and glutathione reductase (GR) in liver decreased in the MCs treated animals. In brain, there were obvious changes in glutathione peroxidase (GPx) and GR, while only CAT was obviously influenced in kidney. Therefore, daily exposure at a lower dosage of MCs, which mimicked a natural route of MCs. could also induce obvious oxidative stress in diverse organs of domestic rabbits. The oxidative stress induced by MCs in brain was as serious as in liver and kidney, suggesting that brain may also be a target of MCs in mammals. And it seems that animals may have more time to metabolize the toxins or to form an adaptive response to reduce the adverse effects when exposed to the low dose of MCs. (C) 2008 Elsevier B.V. All rights reserved.; Oxidative stress response after prolonged exposure to a low dose of microcystins (MCs) was studied in liver, kidney and brain of domestic rabbits. Rabbits were treated with extracted MCs (mainly MC-LR and MC-RR) at a dose of 2 MC-LReq. mu g/kg body weight or saline solution every 24 h for 7 or 14 days. During the exposure of MCs, increase of lipid peroxidation (LPO) levels were detected in all the organs studied, while antioxidant enzymes responded differently among different organs. The enzyme activities Of Superoxide dismutase (SOD). catalase (CAT) and glutathione reductase (GR) in liver decreased in the MCs treated animals. In brain, there were obvious changes in glutathione peroxidase (GPx) and GR, while only CAT was obviously influenced in kidney. Therefore, daily exposure at a lower dosage of MCs, which mimicked a natural route of MCs. could also induce obvious oxidative stress in diverse organs of domestic rabbits. The oxidative stress induced by MCs in brain was as serious as in liver and kidney, suggesting that brain may also be a target of MCs in mammals. And it seems that animals may have more time to metabolize the toxins or to form an adaptive response to reduce the adverse effects when exposed to the low dose of MCs. (C) 2008 Elsevier B.V. All rights reserved. |
| Subtype | Article |
| Keyword | Microcystins Domestic Rabbit Daily Exposure Oxidative Stress |
| Department | [Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; [Zhao, Yanyan; Xie, Ping; Zhang, Xuezhen] Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China |
| Subject Area | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| DOI | 10.1016/j.etap.2008.10.005 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Funding Organization | Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| WOS Subject | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| WOS ID | WOS:000264387200005 |
| WOS Keyword | IN-VIVO ; LR ; HEPATOTOXICITY ; CYANOBACTERIA ; LIVER ; RATS ; MICE ; GLUTATHIONE ; APOPTOSIS ; ENZYMES |
| Funding Organization | Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/152342/7820 |
| Collection | 期刊论文 |
| Corresponding Author | Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China 2.Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Yanyan,Xie, Ping,Zhang, Xuezhen,et al. Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2009,27(2):195-199. |
| APA | Zhao, Yanyan,Xie, Ping,Zhang, Xuezhen,&Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China.(2009).Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,27(2),195-199. |
| MLA | Zhao, Yanyan,et al."Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 27.2(2009):195-199. |
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