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Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins
Zhao, Yanyan2; Xie, Ping1,2; Zhang, Xuezhen2; Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China
2009-03-01
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
Volume27Issue:2Pages:195-199
AbstractOxidative stress response after prolonged exposure to a low dose of microcystins (MCs) was studied in liver, kidney and brain of domestic rabbits. Rabbits were treated with extracted MCs (mainly MC-LR and MC-RR) at a dose of 2 MC-LReq. mu g/kg body weight or saline solution every 24 h for 7 or 14 days. During the exposure of MCs, increase of lipid peroxidation (LPO) levels were detected in all the organs studied, while antioxidant enzymes responded differently among different organs. The enzyme activities Of Superoxide dismutase (SOD). catalase (CAT) and glutathione reductase (GR) in liver decreased in the MCs treated animals. In brain, there were obvious changes in glutathione peroxidase (GPx) and GR, while only CAT was obviously influenced in kidney. Therefore, daily exposure at a lower dosage of MCs, which mimicked a natural route of MCs. could also induce obvious oxidative stress in diverse organs of domestic rabbits. The oxidative stress induced by MCs in brain was as serious as in liver and kidney, suggesting that brain may also be a target of MCs in mammals. And it seems that animals may have more time to metabolize the toxins or to form an adaptive response to reduce the adverse effects when exposed to the low dose of MCs. (C) 2008 Elsevier B.V. All rights reserved.; Oxidative stress response after prolonged exposure to a low dose of microcystins (MCs) was studied in liver, kidney and brain of domestic rabbits. Rabbits were treated with extracted MCs (mainly MC-LR and MC-RR) at a dose of 2 MC-LReq. mu g/kg body weight or saline solution every 24 h for 7 or 14 days. During the exposure of MCs, increase of lipid peroxidation (LPO) levels were detected in all the organs studied, while antioxidant enzymes responded differently among different organs. The enzyme activities Of Superoxide dismutase (SOD). catalase (CAT) and glutathione reductase (GR) in liver decreased in the MCs treated animals. In brain, there were obvious changes in glutathione peroxidase (GPx) and GR, while only CAT was obviously influenced in kidney. Therefore, daily exposure at a lower dosage of MCs, which mimicked a natural route of MCs. could also induce obvious oxidative stress in diverse organs of domestic rabbits. The oxidative stress induced by MCs in brain was as serious as in liver and kidney, suggesting that brain may also be a target of MCs in mammals. And it seems that animals may have more time to metabolize the toxins or to form an adaptive response to reduce the adverse effects when exposed to the low dose of MCs. (C) 2008 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordMicrocystins Domestic Rabbit Daily Exposure Oxidative Stress
Department[Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; [Zhao, Yanyan; Xie, Ping; Zhang, Xuezhen] Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China
Subject AreaEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
DOI10.1016/j.etap.2008.10.005
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationHuazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170]
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000264387200005
WOS KeywordIN-VIVO ; LR ; HEPATOTOXICITY ; CYANOBACTERIA ; LIVER ; RATS ; MICE ; GLUTATHIONE ; APOPTOSIS ; ENZYMES
Funding OrganizationHuazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170] ; Huazhong Agriculture University ; National Natural Science Foundation of China [30530170]
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Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/7820
Collection期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Yanyan,Xie, Ping,Zhang, Xuezhen,et al. Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2009,27(2):195-199.
APA Zhao, Yanyan,Xie, Ping,Zhang, Xuezhen,&Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu S Rd 7, Wuhan 430072, Peoples R China.(2009).Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,27(2),195-199.
MLA Zhao, Yanyan,et al."Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 27.2(2009):195-199.
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