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Toxicological Research on Environmental Endocrine Disruptors
Shi Xiongjie; Liu Chunsheng; Yu Ke; Deng Jun; Yu Liqin; Zhou Bingsheng; Shi, XJ, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2009
Source PublicationPROGRESS IN CHEMISTRY
Volume21Issue:2-3Pages:340-349
AbstractMost evidence in terms of endocrine dsiruptors (EDs) mainly originates from studies on reproductive organs. However, in veterbrates, the ability to attain reproductive and development success relays on the intact organization of a complex endocrine system. Disturbances in the regulation of the key hormones and receptors functioning along this system may cause detrimental effects on reproduction and development. Here we reviewed recent studies of EDs on endocrine system. EDs may act on key hormones and receptors along with the hypothalarnic-pituitary-gonald (HPG) axis and lead to reproductive failure. Thyroid disruption may be caused at different levels, for example, the synthesis, transport, binding and cellular uptake along with the hypothalamic-pituitary-thyroid (HPT) axis. Knowledge of model of action EDs is largely via receptors-mediated pathway and alternatively may affect on steroid hormone synthesis. Aquatic hypoxia can influence fish reproduction and thus it is also an endocrine disruptor. Molecular techniques, such as toxicomics, transgenic fish will be employed as powerful tools for environmental EDs risk assessment, as well as in elucidating mechanisms of model action.
KeywordEndocrine Disruptors Endocrine System Risk Assessment Toxicology
Department[Shi Xiongjie; Liu Chunsheng; Yu Ke; Deng Jun; Yu Liqin; Zhou Bingsheng] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Subject AreaChemistry ; Multidisciplinary
Indexed BySCI
Language英语
WOS IDWOS:000264790400007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/7800
Collection期刊论文
Corresponding AuthorShi, XJ, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Shi Xiongjie,Liu Chunsheng,Yu Ke,et al. Toxicological Research on Environmental Endocrine Disruptors[J]. PROGRESS IN CHEMISTRY,2009,21(2-3):340-349.
APA Shi Xiongjie.,Liu Chunsheng.,Yu Ke.,Deng Jun.,Yu Liqin.,...&Shi, XJ, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.(2009).Toxicological Research on Environmental Endocrine Disruptors.PROGRESS IN CHEMISTRY,21(2-3),340-349.
MLA Shi Xiongjie,et al."Toxicological Research on Environmental Endocrine Disruptors".PROGRESS IN CHEMISTRY 21.2-3(2009):340-349.
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