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Effects of tetrabrominated diphenyl ether and hexabromocyclododecanes in single and complex exposure to hepatoma HepG2 cells
Hu, Xiaozhong1; Hu, Decong1; Xu, Ying2; Hu, XZ, Hubei Entry Exit Inspect & Quarantine Bur PRC, Ctr Technol, Wuhan 430022, Peoples R China
2009-05-01
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
Volume27Issue:3Pages:327-337
AbstractThis study was designed to determine cytotoxic effects of PBDE-47 and HBCDs individually or with a mixture of both compounds exposure to Hep G2 cells. The results showed PBDE-47 and HBCDs induced increase of nitric oxide synthase (NOS) activity, release of NO. dissipation of mitochondria membrane potential and cell apoptosis. Exposure to HBCDs induced ROS formation. Moreover, preincubation with PTIO (NO scavanger) and N-acetylcysteine (ROS scavanger) partially reversed cytotoxic effects of these compounds. The possible mechanism is that PBDE-47 and HBCDs could boost generation of NO and/or ROS, impact mitochondria, and result in start-ups of apoptosis program. Cells exposed to mixture of both compounds and each of them showed non-apoptotic rate significant difference, but the combination of them caused more adverse effects on cells. These results Suggest that PBDE-47 and HBCDs in single and complex exposure have the cytotoxic activity of anti-proliferation and induction of apoptosis in tumor cells in vitro. (C) 2008 Elsevier B.V. All rights reserved.; This study was designed to determine cytotoxic effects of PBDE-47 and HBCDs individually or with a mixture of both compounds exposure to Hep G2 cells. The results showed PBDE-47 and HBCDs induced increase of nitric oxide synthase (NOS) activity, release of NO. dissipation of mitochondria membrane potential and cell apoptosis. Exposure to HBCDs induced ROS formation. Moreover, preincubation with PTIO (NO scavanger) and N-acetylcysteine (ROS scavanger) partially reversed cytotoxic effects of these compounds. The possible mechanism is that PBDE-47 and HBCDs could boost generation of NO and/or ROS, impact mitochondria, and result in start-ups of apoptosis program. Cells exposed to mixture of both compounds and each of them showed non-apoptotic rate significant difference, but the combination of them caused more adverse effects on cells. These results Suggest that PBDE-47 and HBCDs in single and complex exposure have the cytotoxic activity of anti-proliferation and induction of apoptosis in tumor cells in vitro. (C) 2008 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordPbde-47 Hbcds Cytotoxic Effects Complex Exposure
Department[Hu, Xiaozhong; Hu, Decong] Hubei Entry Exit Inspect & Quarantine Bur PRC, Ctr Technol, Wuhan 430022, Peoples R China; [Xu, Ying] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Subject AreaEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
DOI10.1016/j.etap.2008.11.014
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Nature Science Foundation of China [40590390]; General Administration of Quality Supervision, Inspection and Quarantine of P.R.C [2008IK171] ; National Nature Science Foundation of China [40590390]; General Administration of Quality Supervision, Inspection and Quarantine of P.R.C [2008IK171] ; National Nature Science Foundation of China [40590390]; General Administration of Quality Supervision, Inspection and Quarantine of P.R.C [2008IK171] ; National Nature Science Foundation of China [40590390]; General Administration of Quality Supervision, Inspection and Quarantine of P.R.C [2008IK171]
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000265479000004
WOS KeywordBROMINATED FLAME RETARDANTS ; CYTOCHROME-C RELEASE ; BREAST-CANCER CELLS ; NITRIC-OXIDE ; HL-60 CELLS ; IN-VITRO ; DEVELOPMENTAL EXPOSURE ; INDUCED APOPTOSIS ; MISGURNUS-ANGUILLICAUDATUS ; MITOCHONDRIAL-FUNCTION
Funding OrganizationNational Nature Science Foundation of China [40590390]; General Administration of Quality Supervision, Inspection and Quarantine of P.R.C [2008IK171] ; National Nature Science Foundation of China [40590390]; General Administration of Quality Supervision, Inspection and Quarantine of P.R.C [2008IK171] ; National Nature Science Foundation of China [40590390]; General Administration of Quality Supervision, Inspection and Quarantine of P.R.C [2008IK171] ; National Nature Science Foundation of China [40590390]; General Administration of Quality Supervision, Inspection and Quarantine of P.R.C [2008IK171]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/7772
Collection期刊论文
Corresponding AuthorHu, XZ, Hubei Entry Exit Inspect & Quarantine Bur PRC, Ctr Technol, Wuhan 430022, Peoples R China
Affiliation1.Hubei Entry Exit Inspect & Quarantine Bur PRC, Ctr Technol, Wuhan 430022, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Hu, Xiaozhong,Hu, Decong,Xu, Ying,et al. Effects of tetrabrominated diphenyl ether and hexabromocyclododecanes in single and complex exposure to hepatoma HepG2 cells[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2009,27(3):327-337.
APA Hu, Xiaozhong,Hu, Decong,Xu, Ying,&Hu, XZ, Hubei Entry Exit Inspect & Quarantine Bur PRC, Ctr Technol, Wuhan 430022, Peoples R China.(2009).Effects of tetrabrominated diphenyl ether and hexabromocyclododecanes in single and complex exposure to hepatoma HepG2 cells.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,27(3),327-337.
MLA Hu, Xiaozhong,et al."Effects of tetrabrominated diphenyl ether and hexabromocyclododecanes in single and complex exposure to hepatoma HepG2 cells".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 27.3(2009):327-337.
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