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学科主题: Pharmacology & Pharmacy; Toxicology
题名: Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)
作者: Li, Dapeng1, 2; Xie, Ping1, 2; Zhang, Xuezhen2; Zhao, Yanyan2
通讯作者: Ping, X, Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Donghu S Rd 7, Wuhan 430072, Peoples R China
关键词: Microcystins ; Fish ; Blood pressure ; Hemorrhage ; Shock
刊名: TOXICON
发表日期: 2009-05-01
DOI: 10.1016/j.toxicon.2009.01.027
卷: 53, 期:6, 页:638-644
收录类别: SCI
文章类型: Article
部门归属: [Li, Dapeng; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China; [Li, Dapeng; Xie, Ping; Zhang, Xuezhen; Zhao, Yanyan] Huazhong Agr Univ, Coll Fishery, Minist Agr, Key Lab Freshwater Biodivers Conservat & Utilizat, Wuhan 430070, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: Huazhong Agricultural University ; National Basic Research Program of China [2008CB418101]
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
摘要: Circulatory responses of crucian carp injected intraperitoneally with extracted micro-cystins (MCs) were studied at sublethal and lethal doses (150 and 600 mu g MC kg(-1) body mass, respectively). Mean arterial blood pressure (MAP), heart rate, hematocrit (Hct), red blood cell (RBC) counts, and circulating blood volume (BV) were assayed at 0, 1, 3, 12, 24, and 48 h post-toxin administration. MAP decreased significantly in a dose-dependent manner over time. Within the 48-h test period, the lethal dose as well as the sublethal dose resulted in a steady decline of MAP without recovery. Heart rate significantly increased within 24 h post-injection as blood pressure significantly dropped, then showed a terminal decline to the control level. The dose-dependent decreases in BV and Hct were directly related to the drop in MAP. Intraperitoneal injection of a lethal dose of MCs led to hepatic and gill hemorrhage. Consequently, crucian carp given MCs suffered from hypovolemic hypotensive shock. (C) 2009 Elsevier Ltd. All rights reserved.
英文摘要: Circulatory responses of crucian carp injected intraperitoneally with extracted micro-cystins (MCs) were studied at sublethal and lethal doses (150 and 600 mu g MC kg(-1) body mass, respectively). Mean arterial blood pressure (MAP), heart rate, hematocrit (Hct), red blood cell (RBC) counts, and circulating blood volume (BV) were assayed at 0, 1, 3, 12, 24, and 48 h post-toxin administration. MAP decreased significantly in a dose-dependent manner over time. Within the 48-h test period, the lethal dose as well as the sublethal dose resulted in a steady decline of MAP without recovery. Heart rate significantly increased within 24 h post-injection as blood pressure significantly dropped, then showed a terminal decline to the control level. The dose-dependent decreases in BV and Hct were directly related to the drop in MAP. Intraperitoneal injection of a lethal dose of MCs led to hepatic and gill hemorrhage. Consequently, crucian carp given MCs suffered from hypovolemic hypotensive shock. (C) 2009 Elsevier Ltd. All rights reserved.
关键词[WOS]: TROUT ONCORHYNCHUS-MYKISS ; CYCLIC PEPTIDE TOXIN ; RAINBOW-TROUT ; BIOCHEMICAL-CHARACTERIZATION ; CYPRINUS-CARPIO ; BLOOD-PRESSURE ; ORAL TOXICITY ; BROWN TROUT ; LR ; AERUGINOSA
语种: 英语
WOS记录号: WOS:000265358600007
ISSN号: 0041-0101
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/7768
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Coll Fishery, Minist Agr, Key Lab Freshwater Biodivers Conservat & Utilizat, Wuhan 430070, Peoples R China

Recommended Citation:
Li, Dapeng; Xie, Ping; Zhang, Xuezhen; Zhao, Yanyan.Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus),TOXICON,2009,53(6):638-644
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