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Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)
Li, Dapeng; Xie, Ping; Zhang, Xuezhen; Zhao, Yanyan; Ping, X, Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Donghu S Rd 7, Wuhan 430072, Peoples R China
2009
Source PublicationTOXICON
Volume53Issue:6Pages:638-644
AbstractCirculatory responses of crucian carp injected intraperitoneally with extracted micro-cystins (MCs) were studied at sublethal and lethal doses (150 and 600 mu g MC kg(-1) body mass, respectively). Mean arterial blood pressure (MAP), heart rate, hematocrit (Hct), red blood cell (RBC) counts, and circulating blood volume (BV) were assayed at 0, 1, 3, 12, 24, and 48 h post-toxin administration. MAP decreased significantly in a dose-dependent manner over time. Within the 48-h test period, the lethal dose as well as the sublethal dose resulted in a steady decline of MAP without recovery. Heart rate significantly increased within 24 h post-injection as blood pressure significantly dropped, then showed a terminal decline to the control level. The dose-dependent decreases in BV and Hct were directly related to the drop in MAP. Intraperitoneal injection of a lethal dose of MCs led to hepatic and gill hemorrhage. Consequently, crucian carp given MCs suffered from hypovolemic hypotensive shock. (C) 2009 Elsevier Ltd. All rights reserved.
KeywordMicrocystins Fish Blood Pressure Hemorrhage Shock
Department[Li, Dapeng; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China; [Li, Dapeng; Xie, Ping; Zhang, Xuezhen; Zhao, Yanyan] Huazhong Agr Univ, Coll Fishery, Minist Agr, Key Lab Freshwater Biodivers Conservat & Utilizat, Wuhan 430070, Peoples R China
Subject AreaPharmacology & Pharmacy ; Toxicology
Funding OrganizationHuazhong Agricultural University ; National Basic Research Program of China [2008CB418101] ; Huazhong Agricultural University ; National Basic Research Program of China [2008CB418101] ; Huazhong Agricultural University ; National Basic Research Program of China [2008CB418101] ; Huazhong Agricultural University ; National Basic Research Program of China [2008CB418101]
Indexed BySCI
Language英语
WOS IDWOS:000265358600007
Funding OrganizationHuazhong Agricultural University ; National Basic Research Program of China [2008CB418101] ; Huazhong Agricultural University ; National Basic Research Program of China [2008CB418101] ; Huazhong Agricultural University ; National Basic Research Program of China [2008CB418101] ; Huazhong Agricultural University ; National Basic Research Program of China [2008CB418101]
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/7768
Collection期刊论文
Corresponding AuthorPing, X, Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Donghu S Rd 7, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Li, Dapeng,Xie, Ping,Zhang, Xuezhen,et al. Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)[J]. TOXICON,2009,53(6):638-644.
APA Li, Dapeng,Xie, Ping,Zhang, Xuezhen,Zhao, Yanyan,&Ping, X, Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Donghu S Rd 7, Wuhan 430072, Peoples R China.(2009).Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus).TOXICON,53(6),638-644.
MLA Li, Dapeng,et al."Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)".TOXICON 53.6(2009):638-644.
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