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Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1
Yin, Naida; Jin, Xia; He, Jiangyan; Yin, Zhan; Yin, Z, Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan 430072, Hubei, Peoples R China
2009
Source PublicationTOXICOLOGY AND APPLIED PHARMACOLOGY
Volume238Issue:1Pages:20-26
AbstractTeleost vitellogenins (VTGs) are large multidomain apolipoproteins, traditionally considered to be estrogen-responsive precursors of the major egg yolk proteins, expressed and synthesized mainly in hepatic tissue. The inducibility of VTGs has made them one of the most frequently used in vivo and in vitro biomarkers of exposure to estrogen-active substances. A significant level of zebrafish vtgAo1, a major estrogen responsive form, has been unexpectedly found in heart tissue in our present studies. Our studies on zebrafish cardiomyopathy, caused by adrenergic agonist treatment, suggest a similar protective function of the cardiac expressed vtgAo1. We hypothesize that its function is to unload surplus intracellular lipids in cardiomyocytes for "reverse triglyceride transportation" similar to that found in lipid transport proteins in mammals. Our results also demonstrated that zebrafish vtgAo1 mRNA expression in heart can be suppressed by both (x-adrenergic agonist, phenylephrine (PE) and beta-adrenergic agonist, isoproterenol (ISO). Furthermore, the strong stimulation of zebrafish vtgAo1 expression in plasma induced by the beta-adrenergic antagonist, MOXIsylyl, was detected by Enzyme-Linked ImmunoSorbent Assay (ELISA). Such stimulation cannot be suppressed by taMOXIfen, an antagonist to estrogen receptors. Thus, Our present data indicate that the production of teleost VTG in vivo can be regulated not only by estrogenic agents, but by adrenergic signals as well. (c) 2009 Elsevier Inc. All rights reserved.
KeywordZebrafish Vtgao1 Adrenergic Agents Heart Liver
Department[Yin, Naida; Jin, Xia; He, Jiangyan; Yin, Zhan] Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan 430072, Hubei, Peoples R China; [Yin, Naida; Yin, Zhan] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Subject AreaPharmacology & Pharmacy ; Toxicology
Funding OrganizationHi-Tech Research and Development Program of China [2006AA06Z424]; National Natural Science Foundation of China [90608017, 20890113] ; Hi-Tech Research and Development Program of China [2006AA06Z424]; National Natural Science Foundation of China [90608017, 20890113] ; Hi-Tech Research and Development Program of China [2006AA06Z424]; National Natural Science Foundation of China [90608017, 20890113] ; Hi-Tech Research and Development Program of China [2006AA06Z424]; National Natural Science Foundation of China [90608017, 20890113]
Indexed BySCI
Language英语
WOS IDWOS:000267009800003
Funding OrganizationHi-Tech Research and Development Program of China [2006AA06Z424]; National Natural Science Foundation of China [90608017, 20890113] ; Hi-Tech Research and Development Program of China [2006AA06Z424]; National Natural Science Foundation of China [90608017, 20890113] ; Hi-Tech Research and Development Program of China [2006AA06Z424]; National Natural Science Foundation of China [90608017, 20890113] ; Hi-Tech Research and Development Program of China [2006AA06Z424]; National Natural Science Foundation of China [90608017, 20890113]
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Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/7694
Collection期刊论文
Corresponding AuthorYin, Z, Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Yin, Naida,Jin, Xia,He, Jiangyan,et al. Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2009,238(1):20-26.
APA Yin, Naida,Jin, Xia,He, Jiangyan,Yin, Zhan,&Yin, Z, Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan 430072, Hubei, Peoples R China.(2009).Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1.TOXICOLOGY AND APPLIED PHARMACOLOGY,238(1),20-26.
MLA Yin, Naida,et al."Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1".TOXICOLOGY AND APPLIED PHARMACOLOGY 238.1(2009):20-26.
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