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Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins
Li, Li1,2; Xie, Ping1,2; Li, L, Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
2009-08-01
Source PublicationBIOMEDICAL AND ENVIRONMENTAL SCIENCES
ISSN0895-3988
Volume22Issue:4Pages:297-302
AbstractObjective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins (MCs) for further understanding hepatic intoxication and antioxidation mechanism in fish. Methods Phytoplanktivorous silver carp was injected intraperitoneally (i.p.) with extracted hepatotoxic microcystins (mainly MC-RR and -LR) at a dose of 1000 mu g MC-LReq./kg body weight, and liver histopathological changes and antioxidant responses were studied at 1, 3, 12, 24, and 48 h, respectively, after injection. Results The damage to liver structure and the activities of hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxide (GPX) were increased in a time-dependent manner. Conclusion In terms of clinical and histological signs of intoxication and LD50 (i.p.) dose of MC-LR, silver carp appears rather resistant to MCs exposure than other fishes. Also, the significantly increased SOD activity in the liver of silver carp suggests a higher degree of response to MCs exposure than CAT and GPX.; Objective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins (MCs) for further understanding hepatic intoxication and antioxidation mechanism in fish. Methods Phytoplanktivorous silver carp was injected intraperitoneally (i.p.) with extracted hepatotoxic microcystins (mainly MC-RR and -LR) at a dose of 1000 mu g MC-LReq./kg body weight, and liver histopathological changes and antioxidant responses were studied at 1, 3, 12, 24, and 48 h, respectively, after injection. Results The damage to liver structure and the activities of hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxide (GPX) were increased in a time-dependent manner. Conclusion In terms of clinical and histological signs of intoxication and LD(50) (i.p.) dose of MC-LR, silver carp appears rather resistant to MCs exposure than other fishes. Also, the significantly increased SOD activity in the liver of silver carp suggests a higher degree of response to MCs exposure than CAT and GPX.
SubtypeArticle
KeywordAntioxidant Response Histopathological Characteristics Liver Microcystins Fish
Department[Li, Li; Xie, Ping] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China; [Li, Li; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430070, Hubei, Peoples R China
Subject AreaEnvironmental & Occupational Health ; Environmental Sciences ; Public
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China [30700077] ; National Natural Science Foundation of China [30700077] ; National Natural Science Foundation of China [30700077] ; National Natural Science Foundation of China [30700077]
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Public, Environmental & Occupational Health
WOS SubjectEnvironmental Sciences ; Public, Environmental & Occupational Health
WOS IDWOS:000269378300004
WOS KeywordTROUT ONCORHYNCHUS-MYKISS ; CYCLIC PEPTIDE TOXIN ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; LR ; LIVER ; FISH ; BIOACCUMULATION ; AERUGINOSA ; TOXICITY
Funding OrganizationNational Natural Science Foundation of China [30700077] ; National Natural Science Foundation of China [30700077] ; National Natural Science Foundation of China [30700077] ; National Natural Science Foundation of China [30700077]
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/7606
Collection期刊论文
Corresponding AuthorLi, L, Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430070, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Li, Li,Xie, Ping,Li, L, Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China. Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2009,22(4):297-302.
APA Li, Li,Xie, Ping,&Li, L, Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China.(2009).Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,22(4),297-302.
MLA Li, Li,et al."Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 22.4(2009):297-302.
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