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学科主题: Environmental Sciences; Public ; Environmental & Occupational Health
题名: Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins
作者: Li, Li1, 2; Xie, Ping1, 2
通讯作者: Li, L, Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
关键词: Antioxidant response ; Histopathological characteristics ; Liver ; Microcystins ; Fish
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2009-08-01
卷: 22, 期:4, 页:297-302
收录类别: SCI
文章类型: Article
部门归属: [Li, Li; Xie, Ping] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China; [Li, Li; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430070, Hubei, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [30700077]
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
摘要: Objective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins (MCs) for further understanding hepatic intoxication and antioxidation mechanism in fish. Methods Phytoplanktivorous silver carp was injected intraperitoneally (i.p.) with extracted hepatotoxic microcystins (mainly MC-RR and -LR) at a dose of 1000 mu g MC-LReq./kg body weight, and liver histopathological changes and antioxidant responses were studied at 1, 3, 12, 24, and 48 h, respectively, after injection. Results The damage to liver structure and the activities of hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxide (GPX) were increased in a time-dependent manner. Conclusion In terms of clinical and histological signs of intoxication and LD50 (i.p.) dose of MC-LR, silver carp appears rather resistant to MCs exposure than other fishes. Also, the significantly increased SOD activity in the liver of silver carp suggests a higher degree of response to MCs exposure than CAT and GPX.
英文摘要: Objective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins (MCs) for further understanding hepatic intoxication and antioxidation mechanism in fish. Methods Phytoplanktivorous silver carp was injected intraperitoneally (i.p.) with extracted hepatotoxic microcystins (mainly MC-RR and -LR) at a dose of 1000 mu g MC-LReq./kg body weight, and liver histopathological changes and antioxidant responses were studied at 1, 3, 12, 24, and 48 h, respectively, after injection. Results The damage to liver structure and the activities of hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxide (GPX) were increased in a time-dependent manner. Conclusion In terms of clinical and histological signs of intoxication and LD(50) (i.p.) dose of MC-LR, silver carp appears rather resistant to MCs exposure than other fishes. Also, the significantly increased SOD activity in the liver of silver carp suggests a higher degree of response to MCs exposure than CAT and GPX.
关键词[WOS]: TROUT ONCORHYNCHUS-MYKISS ; CYCLIC PEPTIDE TOXIN ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; LR ; LIVER ; FISH ; BIOACCUMULATION ; AERUGINOSA ; TOXICITY
语种: 英语
WOS记录号: WOS:000269378300004
ISSN号: 0895-3988
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/7606
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430070, Hubei, Peoples R China

Recommended Citation:
Li, Li; Xie, Ping.Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins,BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2009,22(4):297-302
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