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学科主题: Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity
题名: Distinct Evolutionary Patterns Between Two Duplicated Color Vision Genes Within Cyprinid Fishes
作者: Li, Zhiqiang1, 2; Gan, Xiaoni1, 2, 3; He, Shunping1
通讯作者: He, SP, Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, 7th Donghu S Rd, Wuhan 430072, Hubei, Peoples R China
关键词: Genome duplication ; Color vision gene ; Positive selection ; Cyprinid fish ; Cavefish ; Sinocyclocheilus
刊名: JOURNAL OF MOLECULAR EVOLUTION
发表日期: 2009-10-01
DOI: 10.1007/s00239-009-9283-9
卷: 69, 期:4, 页:346-359
收录类别: SCI
文章类型: Article
部门归属: [Li, Zhiqiang; Gan, Xiaoni; He, Shunping] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China; [Li, Zhiqiang; Gan, Xiaoni] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Gan, Xiaoni] Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China (NSFC) [2007CB411600, 30530120]
类目[WOS]: Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
摘要: We investigated the molecular evolution of duplicated color vision genes (LWS-1 and SWS2) within cyprinid fish, focusing on the most cavefish-rich genus-Sinocyclocheilus. Maximum likelihood-based codon substitution approaches were used to analyze the evolution of vision genes. We found that the duplicated color vision genes had unequal evolutionary rates, which may lead to a related function divergence. Divergence of LWS-1 was strongly influenced by positive selection causing an accelerated rate of substitution in the proportion of pocket-forming residues. The SWS2 pigment experienced divergent selection between lineages, and no positively selected site was found. A duplicate copy of LWS-1 of some cyprinine species had become a pseudogene, but all SWS2 sequences remained intact in the regions examined in the cyprinid fishes examined in this study. The pseudogenization events did not occur randomly in the two copies of LWS-1 within Sinocyclocheilus species. Some cave species of Sinocyclocheilus with numerous morphological specializations that seem to be highly adapted for caves, retain both intact copies of color vision genes in their genome. We found some novel amino acid substitutions at key sites, which might represent interesting target sites for future mutagenesis experiments. Our data add to the increasing evidence that duplicate genes experience lower selective constraints and in some cases positive selection following gene duplication. Some of these observations are unexpected and may provide insights into the effect of caves on the evolution of color vision genes in fishes.
英文摘要: We investigated the molecular evolution of duplicated color vision genes (LWS-1 and SWS2) within cyprinid fish, focusing on the most cavefish-rich genus-Sinocyclocheilus. Maximum likelihood-based codon substitution approaches were used to analyze the evolution of vision genes. We found that the duplicated color vision genes had unequal evolutionary rates, which may lead to a related function divergence. Divergence of LWS-1 was strongly influenced by positive selection causing an accelerated rate of substitution in the proportion of pocket-forming residues. The SWS2 pigment experienced divergent selection between lineages, and no positively selected site was found. A duplicate copy of LWS-1 of some cyprinine species had become a pseudogene, but all SWS2 sequences remained intact in the regions examined in the cyprinid fishes examined in this study. The pseudogenization events did not occur randomly in the two copies of LWS-1 within Sinocyclocheilus species. Some cave species of Sinocyclocheilus with numerous morphological specializations that seem to be highly adapted for caves, retain both intact copies of color vision genes in their genome. We found some novel amino acid substitutions at key sites, which might represent interesting target sites for future mutagenesis experiments. Our data add to the increasing evidence that duplicate genes experience lower selective constraints and in some cases positive selection following gene duplication. Some of these observations are unexpected and may provide insights into the effect of caves on the evolution of color vision genes in fishes.
关键词[WOS]: POSITIVE DARWINIAN SELECTION ; AMINO-ACID SITES ; ADAPTIVE EVOLUTION ; VISUAL PIGMENTS ; MOLECULAR EVOLUTION ; OPSIN GENES ; MAXIMUM-LIKELIHOOD ; PHYLOGENETIC ANALYSIS ; GENOME DUPLICATION ; SEQUENCE ALIGNMENT
语种: 英语
WOS记录号: WOS:000271460600006
ISSN号: 0022-2844
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/7496
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China

Recommended Citation:
Li, Zhiqiang; Gan, Xiaoni; He, Shunping.Distinct Evolutionary Patterns Between Two Duplicated Color Vision Genes Within Cyprinid Fishes,JOURNAL OF MOLECULAR EVOLUTION,2009,69(4):346-359
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