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学科主题: Biochemistry & Molecular Biology; Fisheries; Physiology
题名: HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP
作者: Zongbin Cui ; Zuoyan Zhu
关键词: COMMON CARP ; CRUCIAN CARP ; GROWTH HORMONE ; GROWTH HORMONE GENE ; TRANSGENIC FISH ; HORMONAL REPLACEMENT ; HYPOPHYSECTOMY
刊名: FISH PHYSIOLOGY AND BIOCHEMISTRY
发表日期: 1993
卷: 12, 期:2, 页:161-169
收录类别: SCI
部门归属: UNIV ABERDEEN,DEPT MOLEC & CELL BIOL,ABERDEEN AB9 2TN,SCOTLAND; CHINESE ACAD SCI,INST HYDROBIOL,WUHAN,HUBEI 430072,PEOPLES R CHINA; UNIV ABERDEEN,DEPT ZOOL,ABERDEEN AB9 2TN,SCOTLAND
摘要: Transgenic common carp, Cyprinus carpio, produced by the microinjection of fertilized eggs with a linearized chimeric plasmid pMThGH, a human growth hormone (hGH) gene with a mouse metallothionein-I (MT) gene promoter in pBR322, were used to produce F1 and F2 transgenics. Following hypophysectomy of the transgenic F2 common carp, non-transgenic common carp and non-transgenic crucian carp, growth was monitored for up to 110 days. In addition, recombinant hGH was injected subcutaenously into a group of the non-transgenic crucian carp. Growth rate analyses indicated that (1) hypophysectomy of non-transgenic common carp and crucian carp results in the cessation of growth, (2) hGH administration can stimulate the growth of hypophysectomized crucian carp and (3) hypophysectomized hGH-transgenic common carp continue to grow in the absence of their own growth hormone, suggesting that the hGH-transgene is being expressed in tissues other than the pituitary.
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/10324
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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Recommended Citation:
Zongbin Cui; Zuoyan Zhu.HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP,FISH PHYSIOLOGY AND BIOCHEMISTRY,1993,12(2):161-169
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