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A SERINE KINASE REGULATES INTRACELLULAR-LOCALIZATION OF SPLICING FACTORS IN THE CELL CYCLE
Jian-fang Gui; William S.Lane; Xiang-dong Fu
1994
Source PublicationNATURE
Volume369Issue:6482Pages:678-682
AbstractSmall nuclear ribonucleoprotein particles (snRNPs) and non-snRNP splicing factors containing a serine/arginine-rich domain (SR proteins) concentrate in 'speckles' in the nucleus of interphase cells(1). It is believed that nuclear speckles act as storage sites for splicing factors while splicing occurs on nascent transcripts(2). Splicing factors redistribute in response to transcription inhibition(3,4) or viral infection(5), and nuclear speckles break down and reform as cells progress through mitosis(6). We have now identified and cloned a kinase, SRPK1, which is regulated by the cell cycle and is specific for SR proteins; this kinase is related to a Caenorhabditis elegans kinase and to the fission yeast kinase Dsk1 (ref. 7). SRPK1 specifically induces the disassembly of nuclear speckles, and a high level of SRPK1 inhibits splicing in vitro. Our results indicate that SRPK1 mag have a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells, and the reorganization of nuclear speckles during mitosis.
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DepartmentUNIV CALIF SAN DIEGO,DIV CELLULAR & MOLEC MED,LA JOLLA,CA 92093; HARVARD UNIV,CAMBRIDGE,MA 02138; CHINESE ACAD SCI,INST HYDROBIOL,WUHAN 430072,PEOPLES R CHINA
Subject AreaMultidisciplinary Sciences
Indexed BySCI
WOS IDWOS:A1994NT45900064
Citation statistics
Cited Times:415[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/10318
Collection期刊论文
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GB/T 7714
Jian-fang Gui,William S.Lane,Xiang-dong Fu. A SERINE KINASE REGULATES INTRACELLULAR-LOCALIZATION OF SPLICING FACTORS IN THE CELL CYCLE[J]. NATURE,1994,369(6482):678-682.
APA Jian-fang Gui,William S.Lane,&Xiang-dong Fu.(1994).A SERINE KINASE REGULATES INTRACELLULAR-LOCALIZATION OF SPLICING FACTORS IN THE CELL CYCLE.NATURE,369(6482),678-682.
MLA Jian-fang Gui,et al."A SERINE KINASE REGULATES INTRACELLULAR-LOCALIZATION OF SPLICING FACTORS IN THE CELL CYCLE".NATURE 369.6482(1994):678-682.
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