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学科主题: Multidisciplinary Sciences
题名: A SERINE KINASE REGULATES INTRACELLULAR-LOCALIZATION OF SPLICING FACTORS IN THE CELL CYCLE
作者: Jian-fang Gui ; William S.Lane ; Xiang-dong Fu
关键词: RICH DOMAINS
刊名: NATURE
发表日期: 1994
卷: 369, 期:6482, 页:678-682
收录类别: SCI
部门归属: UNIV CALIF SAN DIEGO,DIV CELLULAR & MOLEC MED,LA JOLLA,CA 92093; HARVARD UNIV,CAMBRIDGE,MA 02138; CHINESE ACAD SCI,INST HYDROBIOL,WUHAN 430072,PEOPLES R CHINA
摘要: Small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP splicing factors containing a serine/arginine-rich domain (SR proteins) concentrate in 'speckles' in the nucleus of interphase cells(1). It is believed that nuclear speckles act as storage sites for splicing factors while splicing occurs on nascent transcripts(2). Splicing factors redistribute in response to transcription inhibition(3,4) or viral infection(5), and nuclear speckles break down and reform as cells progress through mitosis(6). We have now identified and cloned a kinase, SRPK1, which is regulated by the cell cycle and is specific for SR proteins; this kinase is related to a Caenorhabditis elegans kinase and to the fission yeast kinase Dsk1 (ref. 7). SRPK1 specifically induces the disassembly of nuclear speckles, and a high level of SRPK1 inhibits splicing in vitro. Our results indicate that SRPK1 mag have a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells, and the reorganization of nuclear speckles during mitosis.
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/10318
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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Recommended Citation:
Jian-fang Gui; William S.Lane; Xiang-dong Fu.A SERINE KINASE REGULATES INTRACELLULAR-LOCALIZATION OF SPLICING FACTORS IN THE CELL CYCLE,NATURE,1994,369(6482):678-682
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