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Cytological and biochemical alterations in Carassius auratus hepatocytes from exposure to sediment containing dioxins and related compounds
Wu, WZ; Zhou, BS; Xu, Y; Schramm, KW; Kettrup, A; Wu, WZ, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
1999
Source PublicationARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
Volume37Issue:3Pages:358-363
AbstractCytological and biochemical alterations of crucial carp (Carassius auratus) hepatocytes were characterized after exposure to sediments from a lake contaminated with dioxins and other industrial chemicals. Carp were exposed in 20 L water containing 25, 50, or 100 g of contaminated sediment for 2 and 4 weeks. Ultrastructural changes in the liver were characterized by severe enlargement of hepatocytes. Alterations in the cell. included formation of condensed and irregular cell nucleus, polynuclei, dispersed heterochromatin, enlargement of the nucleolus, and degeneration of the nucleus. Mitochondrial numbers were reduced and cristae were deformed. Myelin figures and lysosomes were increased, and sometimes cell organelles and cell matrix were totally lost after 4 weeks of exposure. The ultrastructural alterations were correlated with exposure time and sediment concentrations. Hepatosometic index was significantly increased in experimental groups at 2 and 4 weeks as compared with the control group. EROD enzyme activities were strongly induced in liver. A trend from rough endoplasmic reticulum (RER) to SER was observed. Our results suggest that the dioxin-like compounds bound by sediment were bioavailable to C. auratus and cause sublethal effects.
KeywordYa-er Lake
DepartmentChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; GSF, Natl Res Ctr Environm & Hlth, Inst Ecol Chem, D-85764 Neuherberg, Germany
Subject AreaEnvironmental Sciences ; Toxicology
Indexed BySCI
WOS IDWOS:000082555500010
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/10176
Collection期刊论文
Corresponding AuthorWu, WZ, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Wu, WZ,Zhou, BS,Xu, Y,et al. Cytological and biochemical alterations in Carassius auratus hepatocytes from exposure to sediment containing dioxins and related compounds[J]. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,1999,37(3):358-363.
APA Wu, WZ,Zhou, BS,Xu, Y,Schramm, KW,Kettrup, A,&Wu, WZ, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(1999).Cytological and biochemical alterations in Carassius auratus hepatocytes from exposure to sediment containing dioxins and related compounds.ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,37(3),358-363.
MLA Wu, WZ,et al."Cytological and biochemical alterations in Carassius auratus hepatocytes from exposure to sediment containing dioxins and related compounds".ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 37.3(1999):358-363.
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