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学科主题: Environmental Sciences; Toxicology; Water Resources
题名: Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon idellus) and mouse protein phosphatases by microcystins
作者: L. Xu ; P. K. S. Lam ; J. Chen ; Y. Zhang ; K. Harada
通讯作者: Lam, PKS, Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
关键词: microcystins ; fish protein phosphatases ; in vitro inhibition
刊名: ENVIRONMENTAL TOXICOLOGY
发表日期: 2000
卷: 15, 期:2, 页:71-75
收录类别: SCI
部门归属: Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China; City Univ Hong Kong, Ctr Environm Sci & Technol, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China; Meijo Univ, Fac Pharm, Nagoya, Aichi 468, Japan
摘要: Microcystins isolated from toxic cyanobacteria are potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A). The inhibitory effects of three structural variants of microcystins (microcystin-LR, -YR, and -RR) on protein phosphatases isolated and purified from the liver and kidney of grass carp (Ctenopharyngodon idellus) were investigated using the P-32 radiometric assay. The relationships between percentage inhibition of protein phosphatase activity and microcystin levels followed a typical dose-dependent sigmoid curve. These results were compared to those obtained from mouse PP2A. The degree and pattern of inhibition of both fish and mouse protein phosphatases by microcystins were similar. Protein phosphatases in crude fish tissue homogenates showed similar inhibition patterns as purified fish PP2A toward microcystins. (C) 2000 by John Wiley & Sons, Inc.
语种: 英语
WOS记录号: WOS:000086543900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/10136
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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.Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon idellus) and mouse protein phosphatases by microcystins,ENVIRONMENTAL TOXICOLOGY,2000,15(2):71-75
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