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Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon idellus) and mouse protein phosphatases by microcystins
L. Xu; P. K. S. Lam; J. Chen; Y. Zhang; K. Harada; Lam, PKS, Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
2000
Source PublicationENVIRONMENTAL TOXICOLOGY
Volume15Issue:2Pages:71-75
AbstractMicrocystins isolated from toxic cyanobacteria are potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A). The inhibitory effects of three structural variants of microcystins (microcystin-LR, -YR, and -RR) on protein phosphatases isolated and purified from the liver and kidney of grass carp (Ctenopharyngodon idellus) were investigated using the P-32 radiometric assay. The relationships between percentage inhibition of protein phosphatase activity and microcystin levels followed a typical dose-dependent sigmoid curve. These results were compared to those obtained from mouse PP2A. The degree and pattern of inhibition of both fish and mouse protein phosphatases by microcystins were similar. Protein phosphatases in crude fish tissue homogenates showed similar inhibition patterns as purified fish PP2A toward microcystins. (C) 2000 by John Wiley & Sons, Inc.
KeywordMicrocystins Fish Protein Phosphatases In Vitro Inhibition
DepartmentChinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China; City Univ Hong Kong, Ctr Environm Sci & Technol, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China; Meijo Univ, Fac Pharm, Nagoya, Aichi 468, Japan
Subject AreaEnvironmental Sciences ; Toxicology ; Water Resources
Indexed BySCI
Language英语
WOS IDWOS:000086543900001
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/10136
Collection期刊论文
Corresponding AuthorLam, PKS, Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
L. Xu,P. K. S. Lam,J. Chen,et al. Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon idellus) and mouse protein phosphatases by microcystins[J]. ENVIRONMENTAL TOXICOLOGY,2000,15(2):71-75.
APA L. Xu,P. K. S. Lam,J. Chen,Y. Zhang,K. Harada,&Lam, PKS, Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China.(2000).Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon idellus) and mouse protein phosphatases by microcystins.ENVIRONMENTAL TOXICOLOGY,15(2),71-75.
MLA L. Xu,et al."Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon idellus) and mouse protein phosphatases by microcystins".ENVIRONMENTAL TOXICOLOGY 15.2(2000):71-75.
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