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学科主题: Developmental Biology
题名: A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression
作者: Yang, ZG; Liu, NG; Lin, S
通讯作者: Lin, S, Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA
关键词: zebrafish ; forebrain ; zinc finger protein
刊名: DEVELOPMENTAL BIOLOGY
发表日期: 2001-03-01
卷: 231, 期:1, 页:138-148
收录类别: SCI
文章类型: Article
部门归属: Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA; Wuhan Univ, Inst Hydrobiol, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Developmental Biology
研究领域[WOS]: Developmental Biology
摘要: Identifcation of the earliest forebrain-specific markers should facilitate the elucidation of molecular events underlying vertebrate forebrain determination and specification. Here we report the sequence and characterization of fez (forebrain embryonic zinc finger), a gene that is specifically expressed in the embryonic forebrain of zebrafish. Fez encodes a putative nuclear zinc finger protein that is highly conserved in Drosophila, zebrafish, Xenopus, mouse, and human. In zebrafish, the expression of fez becomes detectable at the anterior edge of the presumptive neuroectoderm by 70% epiboly. During the segmentation period, its expression is completely restricted to the rostral region of the prospective forebrain. At approximately 24 h postfertilization, fez expression is mostly confined to the telencephalon and the anterior-ventral region of the diencephalon. Although fez expression is present in one-eyed pinhead (oep) and cyclops (cyc) zebrfish mutants, the pattern is altered. Forced expression of fez induces ectopic expression of dlx2 and dlx6, two genes involved in brain development. Knockdown of fez function using a morpholino-based antisense oligo inhibited dlx2 expression in the ventral forebrain. Our studies indicate that fez is one of the earliest markers specific for the anterior neuroectoderm and it may play a role in forebrain development by regulating Dlx gene expression. (C) 2001 Academic Press.
英文摘要: Identifcation of the earliest forebrain-specific markers should facilitate the elucidation of molecular events underlying vertebrate forebrain determination and specification. Here we report the sequence and characterization of fez (forebrain embryonic zinc finger), a gene that is specifically expressed in the embryonic forebrain of zebrafish. Fez encodes a putative nuclear zinc finger protein that is highly conserved in Drosophila, zebrafish, Xenopus, mouse, and human. In zebrafish, the expression of fez becomes detectable at the anterior edge of the presumptive neuroectoderm by 70% epiboly. During the segmentation period, its expression is completely restricted to the rostral region of the prospective forebrain. At approximately 24 h postfertilization, fez expression is mostly confined to the telencephalon and the anterior-ventral region of the diencephalon. Although fez expression is present in one-eyed pinhead (oep) and cyclops (cyc) zebrfish mutants, the pattern is altered. Forced expression of fez induces ectopic expression of dlx2 and dlx6, two genes involved in brain development. Knockdown of fez function using a morpholino-based antisense oligo inhibited dlx2 expression in the ventral forebrain. Our studies indicate that fez is one of the earliest markers specific for the anterior neuroectoderm and it may play a role in forebrain development by regulating Dlx gene expression. (C) 2001 Academic Press.
关键词[WOS]: BONE MORPHOGENETIC PROTEIN-4 ; ONE-EYED PINHEAD ; PRIMITIVE ENDODERM ; DANIO-RERIO ; NO TAIL ; XENOPUS ; GASTRULATION ; ORGANIZER ; MOUSE ; HEAD
语种: 英语
WOS记录号: WOS:000167271000011
ISSN号: 0012-1606
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/10032
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA
2.Wuhan Univ, Inst Hydrobiol, Wuhan 430072, Peoples R China

Recommended Citation:
Zhongan Yang; Ningai Liu and Shuo Lin.A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression,DEVELOPMENTAL BIOLOGY,2001,231(1):138-148
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