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A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression
Zhongan Yang; Ningai Liu and Shuo Lin; Lin, S, Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA
2001
Source PublicationDEVELOPMENTAL BIOLOGY
Volume231Issue:1Pages:138-148
AbstractIdentifcation of the earliest forebrain-specific markers should facilitate the elucidation of molecular events underlying vertebrate forebrain determination and specification. Here we report the sequence and characterization of fez (forebrain embryonic zinc finger), a gene that is specifically expressed in the embryonic forebrain of zebrafish. Fez encodes a putative nuclear zinc finger protein that is highly conserved in Drosophila, zebrafish, Xenopus, mouse, and human. In zebrafish, the expression of fez becomes detectable at the anterior edge of the presumptive neuroectoderm by 70% epiboly. During the segmentation period, its expression is completely restricted to the rostral region of the prospective forebrain. At approximately 24 h postfertilization, fez expression is mostly confined to the telencephalon and the anterior-ventral region of the diencephalon. Although fez expression is present in one-eyed pinhead (oep) and cyclops (cyc) zebrfish mutants, the pattern is altered. Forced expression of fez induces ectopic expression of dlx2 and dlx6, two genes involved in brain development. Knockdown of fez function using a morpholino-based antisense oligo inhibited dlx2 expression in the ventral forebrain. Our studies indicate that fez is one of the earliest markers specific for the anterior neuroectoderm and it may play a role in forebrain development by regulating Dlx gene expression. (C) 2001 Academic Press.
KeywordZebrafish Forebrain Zinc Finger Protein
DepartmentMed Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA; Wuhan Univ, Inst Hydrobiol, Wuhan 430072, Peoples R China
Subject AreaDevelopmental Biology
Indexed BySCI
WOS IDWOS:000167271000011
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/10032
Collection期刊论文
Corresponding AuthorLin, S, Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA
Recommended Citation
GB/T 7714
Zhongan Yang,Ningai Liu and Shuo Lin,Lin, S, Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA. A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression[J]. DEVELOPMENTAL BIOLOGY,2001,231(1):138-148.
APA Zhongan Yang,Ningai Liu and Shuo Lin,&Lin, S, Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA.(2001).A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression.DEVELOPMENTAL BIOLOGY,231(1),138-148.
MLA Zhongan Yang,et al."A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression".DEVELOPMENTAL BIOLOGY 231.1(2001):138-148.
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